Results 51 to 60 of about 23,011 (262)
New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]
, 2016 Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core +2 more sources
JIMD Reports, Volume 67, Issue 1, January 2026.ABSTRACT Phenylketonuria (PKU) is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH), leading to the accumulation of phenylalanine (Phe) and an increased risk of developmental disorders. Treatment involves a Phe‐restricted diet, amino acid supplements, and for a subset of patients, a tetrahydrobiopterin (BH4 ...
Per Lundkvist +3 more
wiley +1 more source
Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
Antioxidants, 2022 Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper ...
Jennyffer Souza +8 more
doaj +1 more source
Tetrahydrobiopterin biosynthesis, regeneration and functions [PDF]
Biochemical Journal, 2000 Tetrahydrobiopterin (BH4) cofactor is essential for various processes, and is present in probably every cell or tissue of higher organisms. BH4 is required for various enzyme activities, and for less defined functions at the cellular level.
B, Thöny, G, Auerbach, N, Blau
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 2, Page 349-363, January 2026.Background and Purpose Current dogma in stroke is that neuronal nitric oxide synthase (NOS1) exacerbates ischaemic brain injury, while endothelial nitric oxide synthase (NOS3) is protective. However, oxidative stress from ischaemia–reperfusion and oxygen–glucose deprivation‐reoxygenation (OGD/R) is known to uncouple NOS, leading to increased production
Venkata N. Sure +5 more
wiley +1 more source
Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder
Frontiers in Pediatrics, 2014 Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited.
Richard Eugene Frye, Daniel eRossignol
doaj +1 more source
Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]
, 2015 UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A +2 more
core +3 more sources
Analgesia by inhibiting tetrahydrobiopterin synthesis [PDF]
Current Opinion in Pharmacology, 2012 Physiological control of the co-factor tetrahydrobiopterin (BH4) is tight in normal circumstances but levels increase pathologically in the injured somatosensory system. BH4 is an essential co-factor in the production of serotonin, dopamine, epinephrine, norepinephrine and nitric oxide.
Michael, Costigan +2 more
openaire +2 more sources
Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions
Advanced Science, Volume 12, Issue 46, December 11, 2025.Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley +1 more source
Tetrahydrobiopterin Deficiency: From Phenotype to Genotype
Pteridines, 1993 As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad +3 more
doaj +1 more source