Results 51 to 60 of about 20,671 (210)
Blocked dihydropteridines as nitric oxide synthase activators [PDF]
, 2010 It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon +5 more
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Cell Proliferation, EarlyView.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells
Pteridines, 1999 We examined the effects of insulin on tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells (MBMECs). Treatment of MBMECs with insulin increased the intracellular BH4 content in a time- and concentration-dependent manner. The
Ishi Masakazu +4 more
doaj +1 more source
The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification
Life, 2021 The gene encoding alkylglycerol monooxygenase (AGMO) was assigned 10 years ago. So far, AGMO is the only known enzyme capable of catalysing the breakdown of alkylglycerols and lyso-alkylglycerophospholipids. With the knowledge of the genetic information,
Sabrina Sailer +3 more
doaj +1 more source
New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]
, 2016 Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core +2 more sources
Tetrahydrobiopterin biosynthesis, regeneration and functions [PDF]
Biochemical Journal, 2000 Tetrahydrobiopterin (BH4) cofactor is essential for various processes, and is present in probably every cell or tissue of higher organisms. BH4 is required for various enzyme activities, and for less defined functions at the cellular level.
B, Thöny, G, Auerbach, N, Blau
openaire +2 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.The current study uncovered aggravated cerebral ischemic injury and neurological dysfunction following diabetic stroke, in which ferroptosis was involved. SLC7A11 expression was inhibited in the early stages of reperfusion during diabetic stroke, and both ferroptosis inhibitors and neuron‐specific enforced expression of SLC7A11 mitigated neuronal lipid
Siyuan Liu +13 more
wiley +1 more source
Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation [PDF]
, 1994 Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase.
Bechstein, W. O. +6 more
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Analgesia by inhibiting tetrahydrobiopterin synthesis [PDF]
Current Opinion in Pharmacology, 2012 Physiological control of the co-factor tetrahydrobiopterin (BH4) is tight in normal circumstances but levels increase pathologically in the injured somatosensory system. BH4 is an essential co-factor in the production of serotonin, dopamine, epinephrine, norepinephrine and nitric oxide.
Michael, Costigan +2 more
openaire +2 more sources
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
wiley +1 more source