Results 81 to 90 of about 20,671 (210)

Response of Phenylketonuria to Tetrahydrobiopterin [PDF]

The Journal of Nutrition, 2007
A favorable response, indicated by decline of blood phenylalanine (Phe) in patients with phenylketonuria (PKU), to orally administered 6-R-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4) has been reported in many countries following the first publication in 1999. In this review, we describe the experience in the United States with PKU patients and their
Kimberlee, Michals-Matalon, Gita, Bhatia, Flemming, Guttler, Stephen K, Tyring, Reuben, Matalon   +4 more
openaire   +2 more sources

Skin Colour in Salamanders Is Modulated by Both Epitranscriptomic Methylation and Gene Expression

Molecular Ecology, Volume 35, Issue 6, March 2026.
ABSTRACT Animal colouration is a key trait in organismal biology, being involved in natural and sexual selection, competition, and communication. Amphibians use their highly diverse colouration in many ecological interactions, but the molecular bases of their colour variation are less well understood than in other vertebrate systems. While the genetic,
Nicholas Strowbridge, David R. Vieites, Michael G. Ritchie, Kathryn R. Elmer   +3 more
wiley   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells

Pteridines, 2003
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi, Miyasaka Yoshiyuki, Yamamoto Shinichiro, Ishii Masakazu, Kiuchi Yuji   +4 more
doaj   +1 more source

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase.
Jennifer Romanowicz, Camille Leonetti, Zaenab Dhari, Ludmila Korotcova, Shruti D. Ramachandra, Nemanja Saric, Paul D. Morton, Shivani Bansal, Amrita Cheema, Vittorio Gallo, Richard A. Jonas, Nobuyuki Ishibashi   +11 more
doaj   +1 more source

Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]

, 2015
UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A, Rao, Minxi, Smith, Brian C   +2 more
core   +3 more sources

Association Between Peripheral IL‐6 Levels in the Acute Stage of Stroke and Poststroke Depression: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
This is a meta‐analysis on the relationship between IL‐6 concentration in the acute phase of stroke and poststroke depression. Higher peripheral IL‐6 concentrations in the acute stage of stroke are closely related to the risk of PSD; collecting samples within 1 day after stroke onset and evaluating depression post discharge are recommended.
Hongmin Gong, Jiaqin Yuan, Min Li, Deqi Xiong, Fayang Ling, Mei Liu, Yan Hu, Shouqiang Wang   +7 more
wiley   +1 more source

Three classes of tetrahydrobiopterin-dependent enzymes

Pteridines, 2013
Current knowledge distinguishes three classes of tetrahydrobiopterin-dependent enzymes as based on protein sequence similarity. These three protein sequence clusters hydroxylate three types of substrate atoms and use three different forms of iron for ...
Werner Ernst R.
doaj   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Early Diagnosis of 6-Pyruvoyl-tetrahydropterin Synthase Deficiency

Pteridines, 1994
6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, which used to be called dihydrobiopterin synthase deficiency, is the most common kind of tetrahydrobiopterin deficiency. Early treatment by administration of tetrahydrobiopterin and neurotransmitter
Shintaku Haruo
doaj   +1 more source

Linoleic acid-induced endothelial activation

Journal of Lipid Research, 2004
Hypertriglyceridemia, an important risk factor of atherosclerosis, is associated with increased circulating free fatty acids. Research to date indicates that linoleic acid (LA), the major fatty acid in the American diet, may be atherogenic by activating ...
Viswanathan Saraswathi, Guoyao Wu, Michal Toborek, Bernhard Hennig   +3 more
doaj   +1 more source