Results 81 to 90 of about 26,569 (299)

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, Volume 97, Issue 5, Page 809-825, May 2025.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.

Journal of Crohn's & Colitis, 2016
BACKGROUND AND AIMS Guanosine triphosphate cyclohydrolase [GCH1] governs the production of the enzyme cofactor tetrahydrobiopterin [BH4] which is essential for biogenic amine synthesis, lipid metabolism via alkylglycerol monooxygenase [AGMO], and redox ...
Katja Zschiebsch, C. Fischer, G. Pickert, A. Häussler, H. Radeke, S. Grösch, N. Ferreirós, G. Geisslinger, E. Werner, I. Tegeder   +9 more
semanticscholar   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
wiley   +1 more source

Maintenance of cellular tetrahydrobiopterin homeostasis

BMB Reports, 2010
Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and ...
Hye-Lim Kim, Young Shik Park
openaire   +4 more sources

Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.

Antioxidants and Redox Signaling, 2015
AIMS Nitric oxide (NO) derived from endothelial NO synthase (eNOS) has been implicated in the adaptive response to hypoxia. An imbalance between 5,6,7,8-tetrahydrobiopterin (BH4) and 7,8-dihydrobiopterin (BH2) can result in eNOS uncoupling and the ...
K. Chalupský, D. Kračun, I. Kanchev, K. Bertram, A. Görlach   +4 more
semanticscholar   +1 more source

Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Excessive local inflammation is a common mechanism in many cardiovascular diseases (CVDs) such as hypertension, atherosclerosis and aortic aneurysms. In endothelial cells, inflammatory cytokines such as interferons, tumour necrosis factor alpha or interleukins increase oxidative stress and contractile prostanoids and the expression of adhesion
Ana M. Briones, Raquel Hernanz, Ana B. García‐Redondo, Cristina Rodríguez, Luis M. Blanco‐Colio, Almudena Val‐Blasco, María J. Alonso, Mercedes Salaices   +7 more
wiley   +1 more source

Blocked dihydropteridines as nitric oxide synthase activators [PDF]

, 2010
It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon, Gazur, Ben, Gibson, C.L., McInnes, Craig R., Morthala, Raghavendar R., Suckling, C.J.   +5 more
core  

Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction [PDF]

, 2016
Ischaemic heart disease and cerebrovascular disease are the leading causes of morbidity and mortality in the world. The underlying progression of the disease is linked to a reduction in the bioavailability of nitric oxide. One factor contributing to this
Cerrato, Ruha
core   +1 more source

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases

Pteridines, 2006
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide ...
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase.
Jennifer Romanowicz, Camille Leonetti, Zaenab Dhari, Ludmila Korotcova, Shruti D. Ramachandra, Nemanja Saric, Paul D. Morton, Shivani Bansal, Amrita Cheema, Vittorio Gallo, Richard A. Jonas, Nobuyuki Ishibashi   +11 more
doaj   +1 more source