Results 1 to 10 of about 3,816 (178)
The role of tetramethylpyrazine and paeoniflorin in modulating iron metabolism and ferroptosis: innovative strategies for atherosclerosis treatment [PDF]
Frontiers in PharmacologyIntroductionAtherosclerosis (AS) is driven by lipid accumulation, inflammation, and oxidative stress, leading to endothelial dysfunction and plaque formation.
Miao Zhang +8 more
doaj +2 more sources
Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury [PDF]
BiomoleculesBackground: Mitophagy is a critical mitochondrial quality control mechanism that limits neuronal injury following cerebral ischemia/reperfusion injury (CI/RI).
Lanxi Xu +9 more
doaj +2 more sources
Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes [PDF]
Frontiers in PharmacologyOur study focused on the role of traditional Chinese medicine in stroke therapy, specifically targeting endothelin-1 (ET-1) in astrocytes to alleviate ischemic brain injury.
Minzhen Deng +19 more
doaj +2 more sources
Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms
Frontiers in Pharmacology, 2021 Cancer remains a major public health threat. The mitigation of the associated morbidity and mortality remains a major research focus. From a molecular biological perspective, cancer is defined as uncontrolled cell division and abnormal cell growth caused
Shaojie Yang +12 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia ...
Xue-feng Feng +16 more
doaj +1 more source
Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
Frontiers in Pharmacology, 2022 Central nervous system (CNS) diseases can lead to motor, sensory, speech, cognitive dysfunction, and sometimes even death. These diseases are recognized to cause a substantial socio-economic impact on a global scale.
Yue Liu +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alzheimer's disease (AD), one of the most common neurodegenerative diseases, has no effective treatment. We studied the potential effects of tetramethylpyrazine (TMP), an alkaloid in the rhizome of Ligusticum chuanxiong Hort.
Xianfeng Huang +7 more
doaj +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2023 Objective: Ligustrazine is an amide alkaloid, with the active substance being Chuanxiong. Also known as tetramethylpyrazine (TMP), ligustrazine has various pharmacological effects and has been used to treat a variety of diseases.
Yulu Hu, Ao Wang, Jie Chen, Hui Chen
doaj +1 more source
Foods, 2023 Sauce-flavor Baijiu is representative of solid-state fermented Baijiu. It is significant to deeply reveal the dynamic changes of microorganisms in the manufacturing process and their impact on the formation of flavor chemicals correlated with the quality
Youqiang Xu +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The aim of this study was to investigate the time dependent effects of tetramethylpyrazine (TMP, main activity compound of Ligusticum chuanxiong Hort) on two neurological disorders and their neuropsychiatric comorbidities. 6 Hz corneal rapid kindling was
Yue-Peng Jiang +9 more
doaj +1 more source