Results 1 to 10 of about 282 (87)

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms

Frontiers in Pharmacology, 2021
Cancer remains a major public health threat. The mitigation of the associated morbidity and mortality remains a major research focus. From a molecular biological perspective, cancer is defined as uncontrolled cell division and abnormal cell growth caused
Wang Jingnan, Yang Shaojie, Wu Shuodong   +2 more
exaly   +3 more sources

Microneedle-Assisted Percutaneous Delivery of a Tetramethylpyrazine-Loaded Microemulsion

Molecules, 2017
This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN).
Liuqing Di, Xiao-Lin Bi, Ren Zhang
exaly   +3 more sources

Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes

Frontiers in Cellular Neuroscience, 2023
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia ...
Xue-feng Feng, Xue-feng Feng, Ming-cong Li, Ming-cong Li, Zi-yue Lin, Zi-yue Lin, Man-zhong Li, Man-zhong Li, Yun Lu, Yun Lu, Yu-ming Zhuang, Yu-ming Zhuang, Jian-feng Lei, Lei Wang, Lei Wang, Hui Zhao, Hui Zhao   +16 more
doaj   +1 more source

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review

Frontiers in Pharmacology, 2022
Central nervous system (CNS) diseases can lead to motor, sensory, speech, cognitive dysfunction, and sometimes even death. These diseases are recognized to cause a substantial socio-economic impact on a global scale.
Yue Liu, Guang Yang, Wenqiang Cui, Wenqiang Cui, Yunling Zhang, Xiao Liang   +5 more
doaj   +1 more source

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease

Frontiers in Cell and Developmental Biology, 2021
Alzheimer's disease (AD), one of the most common neurodegenerative diseases, has no effective treatment. We studied the potential effects of tetramethylpyrazine (TMP), an alkaloid in the rhizome of Ligusticum chuanxiong Hort.
Xianfeng Huang, Jinyao Yang, Jinyao Yang, Xi Huang, Zaijun Zhang, Jianjun Liu, Liangyu Zou, Xifei Yang   +7 more
doaj   +1 more source

Ligustrazine: A Review of Its Role and Mechanism in the Treatment of Obstetrical and Gynecological Diseases

Clinical and Experimental Obstetrics & Gynecology, 2023
Objective: Ligustrazine is an amide alkaloid, with the active substance being Chuanxiong. Also known as tetramethylpyrazine (TMP), ligustrazine has various pharmacological effects and has been used to treat a variety of diseases.
Yulu Hu, Ao Wang, Jie Chen, Hui Chen
doaj   +1 more source

Characteristics and Correlation of the Microbial Communities and Flavor Compounds during the First Three Rounds of Fermentation in Chinese Sauce-Flavor Baijiu

Foods, 2023
Sauce-flavor Baijiu is representative of solid-state fermented Baijiu. It is significant to deeply reveal the dynamic changes of microorganisms in the manufacturing process and their impact on the formation of flavor chemicals correlated with the quality
Youqiang Xu, Mengqin Wu, Jialiang Niu, Mengwei Lin, Hua Zhu, Kun Wang, Xiuting Li, Baoguo Sun   +7 more
doaj   +1 more source

Inconsistent Time-Dependent Effects of Tetramethylpyrazine on Primary Neurological Disorders and Psychiatric Comorbidities

Frontiers in Pharmacology, 2021
The aim of this study was to investigate the time dependent effects of tetramethylpyrazine (TMP, main activity compound of Ligusticum chuanxiong Hort) on two neurological disorders and their neuropsychiatric comorbidities. 6 Hz corneal rapid kindling was
Yue-Peng Jiang, Yan Jin, Jie Bao, Song Wang, Wei-Dong Lai, Cheng-Ping Wen, Zheng-Hao Xu, Zheng-Hao Xu, Jie Yu, Jie Yu   +9 more
doaj   +1 more source

Ligusticum chuanxiong prevents high‐fat‐diet‐induced lipid metabolism disorder in mice by modulating the genes in the cholesterol pathway

Food Frontiers, 2023
Ligusticum chuanxiong (LC) has been widely used for cardiovascular and cerebrovascular diseases. LC Hort extraction (LCE) can regulate high‐fat‐diet (HFD)‐induced lipid metabolic disorders (LMDs).
Huifang Ge, Xianjiang Ye, Qihe Chen, Jia Ye, Jicheng Chen   +4 more
doaj   +1 more source

Optimization of Molasses and Soybean Meal Content to Enhance Tetramethylpyrazine Yield by Bacillus sp. TTMP20

Molecules, 2023
Microbial fermentation for the production of tetramethylpyrazine (TTMP) is considered to be the most promising method, and the development of a cheap fermentation substrate is of great importance for large-scale TTMP production.
Yujia Li, Shanling Gan, Lirong Luo, Wenjing Yang, Lei Mo, Changhua Shang   +5 more
doaj   +1 more source