Results 11 to 20 of about 3,627 (215)

Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. [PDF]

JAMA Netw Open
ImportanceTetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).ObjectiveTo evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.Design, Setting, and ParticipantsThis phase 2, multicenter,
Liu X, Shang H, Wei Q, Yao X, Lian L, Dang J, Jia R, Wu Z, Li H, Niu Q, Cheng X, Zou Z, Chen S, Zhang M, Liu Y, Liu Y, Liu Q, Huang X, Wang H, Feng H, Wang S, Fan D, TBNALS group.   +22 more
europepmc   +4 more sources

Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms [PDF]

Frontiers in Pharmacology, 2021
Cancer remains a major public health threat. The mitigation of the associated morbidity and mortality remains a major research focus. From a molecular biological perspective, cancer is defined as uncontrolled cell division and abnormal cell growth caused
Shaojie Yang, Shuodong Wu, Wanlin Dai, Liwei Pang, Yaofeng Xie, Tengqi Ren, Xiaolin Zhang, Shiyuan Bi, Yuting Zheng, Jingnan Wang, Yang Sun, Zhuyuan Zheng, Jing Kong   +12 more
doaj   +3 more sources

Effects of Tetramethylpyrazine on Portal Hypertensive Rats

Journal of Pharmacy and Pharmacology, 1998
AbstractThe effects of tetramethylpyrazine, an alkaloid isolated from a Chinese herb Ligusticum wallichii Franch have been assessed in portal hypertensive rats.Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. Two weeks after ligation, when the hyperdynamic state had stabilized, rats were anaesthetized after an ...
F C, Chang, K J, Chen, J G, Lin, C Y, Hong, Y T, Huang   +4 more
openaire   +3 more sources

Tetramethylpyrazine from [PDF]

Natural Product Communications, 2015
For the first time, the bioactive compound tetramethylpyrazine (TMP) was isolated and identified from the culture of Pleurotus geesteranus Singer. Its identification was confirmed unambiguously by identical retention time and mass spectrum to those of a ...
Hengsheng Shen, Huaizhi Liu, Junchen Chen, Suqin Shao, Honghui Zhu, Rong Tsao, Ting Zhou   +6 more
doaj   +3 more sources

Engineered Bacillus subtilis for the Production of Tetramethylpyrazine,(R,R)-2,3-Butanediol and Acetoin

Fermentation, 2023
2,3-Butanediol, acetoin and tetramethylpyrazine have a wide range of applications as important chemicals in the chemical, food and pharmaceutical fields.
Lin Shi, Yuan Lin, Jiaao Song, Hongxing Li, Yinhao Gao, Yonghong Lin, Xiaowen Huang, Wu Meng, Weishuai Qin   +8 more
doaj   +2 more sources

Production of Tetramethylpyrazine from Cane Molasses by Bacillus sp. TTMP20

Molecules, 2023
2,3,5,6-Tetramethylpyrazine (TTMP) is an active ingredient of Ligusticum wallichii Franch. It can be used in medicine and food fields. In this study, Bacillus sp. TTMP20 was applied to produce TTMP using cane molasses as a carbon source.
Yujia Li, Lirong Luo, Xiaoxiao Ding, Xiumin Zhang, Shanling Gan, Changhua Shang   +5 more
doaj   +2 more sources

Tetramethylpyrazine-Inducible Promoter Region from Rhodococcus jostii TMP1

Molecules, 2018
An inducible promoter region, PTTMP (tetramethylpyrazine [TTMP]), has been identified upstream of the tpdABC operon, which contains the genes required for the initial degradation of 2,3,5,6-tetramethylpyrazine in Rhodococcus jostii TMP1 bacteria. In this
Rūta Stanislauskienė, Simonas Kutanovas, Laura Kalinienė, Maksim Bratchikov, Rolandas Meškys   +4 more
doaj   +2 more sources

Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury [PDF]

Biomolecules
Background: Mitophagy is a critical mitochondrial quality control mechanism that limits neuronal injury following cerebral ischemia/reperfusion injury (CI/RI).
Lanxi Xu, Meiyu Wang, Yan Feng, Sihan Wang, Yihan Qian, Weiru Jiang, Jiadong Xu, Yan Fang, Yani Zhang, Lisheng Chu   +9 more
doaj   +2 more sources

Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes [PDF]

Frontiers in Pharmacology
Our study focused on the role of traditional Chinese medicine in stroke therapy, specifically targeting endothelin-1 (ET-1) in astrocytes to alleviate ischemic brain injury.
Minzhen Deng, Minzhen Deng, Minzhen Deng, Yuefang Cai, Yuefang Cai, Yu Wang, Dafeng Hu, Yan Li, Zhenqiu Ning, Chengyi Wang, Sookja Kim Chung, Yan Huang, Yan Huang, Jingbo Sun, Jingbo Sun, Lihua Zhou, Jie Li, Xiao Cheng, Xiao Cheng, Xiao Cheng   +19 more
doaj   +2 more sources

Borneol and Α-asarone as adjuvant agents for improving blood–brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors

Drug Delivery, 2018
Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain–blood barrier (BBB) permeability limited their clinical application.
Jun-Yong Wu, Yong-Jiang Li, Xiong-Bin Hu   +2 more
exaly   +2 more sources