From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health [PDF]
Frontiers in PharmacologyTetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine Ligusticum wallichii (Chuanxiong), has gained significant attention for its therapeutic potential in cerebrovascular diseases and cognitive impairment, mainly ...
Xiaodi Wang +4 more
doaj +2 more sources
Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis [PDF]
OrganogenesisTetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes and oxidative stress in EMs. After establishment of an EMs rat model, rats were
Ke Xu +3 more
doaj +2 more sources
Changes of tetramethylpyrazine-producing functional microorganisms during stacking fermentation in the 1st (Xiasha) and the 2nd (Zaosha) rounds of sauce-flavor Baijiu production [PDF]
Zhongguo niangzaoTetramethylpyrazine (TTMP) is an important flavor substance in sauce-flavor (Jiangxiangxing) Baijiu, showing sweet, nutty and floral aromas, which is one of the important health factors of Chinese Baijiu. In this paper, using fermented grains of stacking
LONG Yafei, ZHU Zi, GUO Chunqin, RAN Guangyao, HU Zhihui, WU Deguang
doaj +2 more sources
Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition [PDF]
Frontiers in PharmacologyTetramethylpyrazine (TMP) is an active component of the Chuanxiong, effectively crosses blood-brain barrier (BBB). It exhibits neuroprotective potential in cerebral ischemia-reperfusion injury (CIRI). This study performed middle cerebral artery occlusion/
Yixin Zhang +4 more
doaj +2 more sources
Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis [PDF]
Reproductive Sciences, 2022 AbstractThe development of more efficacious, non-hormonal therapeutics for endometriosis is still an unmet medical need begging to be fulfilled. Growing evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair, and, as such, platelets play an important role in lesional progression. Tetramethylpyrazine (TMP),
Shenghui Huang +3 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2023 2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia ...
Xue-feng Feng +16 more
doaj +1 more source
Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
Frontiers in Pharmacology, 2022 Central nervous system (CNS) diseases can lead to motor, sensory, speech, cognitive dysfunction, and sometimes even death. These diseases are recognized to cause a substantial socio-economic impact on a global scale.
Yue Liu +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alzheimer's disease (AD), one of the most common neurodegenerative diseases, has no effective treatment. We studied the potential effects of tetramethylpyrazine (TMP), an alkaloid in the rhizome of Ligusticum chuanxiong Hort.
Xianfeng Huang +7 more
doaj +1 more source
Isolation of Tetramethylpyrazine from Culture of Bacillus natto, and Biosynthetic Pathways of Tetramethylpyrazine [PDF]
Nature, 1962 As has been shown in the previous communication1, we have obtained tetramethylpyrazine from cultures of a strain of Bacillus subtilis and it had the characteristic smell of fermented soybean. The fermented soybean is the favourite food as ‘natto’ among Japanese people. The isolation of tetramethylpyrazine from ‘natto’ has been described2.
T, KOSUGE, T, ADACHI, H, KAMIYA
openaire +2 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 Objective: Ligustrazine is an amide alkaloid, with the active substance being Chuanxiong. Also known as tetramethylpyrazine (TMP), ligustrazine has various pharmacological effects and has been used to treat a variety of diseases.
Yulu Hu, Ao Wang, Jie Chen, Hui Chen
doaj +1 more source