Results 41 to 50 of about 3,627 (215)

A Green Route for High-Yield Production of Tetramethylpyrazine From Non-Food Raw Materials

Frontiers in Bioengineering and Biotechnology, 2022
2,3,5,6-Tetramethylpyrazine (TMP) is an active pharmaceutical ingredient originally isolated from Ligusticum wallichii for curing cardiovascular and cerebrovascular diseases and is widely used as a popular flavoring additive in the food industry.
Jing Li, Jian Lu, Zhilin Ma, Jianxiu Li, Xianrui Chen, Mengxue Diao, Nengzhong Xie   +6 more
doaj   +1 more source

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

Frontiers in Pharmacology, 2019
Background: We previously demonstrated that a Danshensu-Tetramethylpyrazine conjugate DT-010 enhanced anticancer effect of doxorubicin (Dox) in Dox-sensitive human breast cancer cells, and protected against Dox-induced cardiotoxicity.
Xinhua Zhou, Anqi Wang, Anqi Wang, Liang Wang, Jianhua Yin, Jianhua Yin, Li Wang, Lijun Di, Maggie Pui-Man Hoi, Luchen Shan, Xu Wu, Xu Wu, Yuqiang Wang   +12 more
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Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems

Frontiers in Pharmacology, 2020
The aim of this study was to assess the underlying impact of Tetramethylpyrazine (TMP), which is the main activity compound of Ligusticum chuanxiong Hort, on the blood–brain barrier, inflammatory and nitrous oxide systems in a rat model of ...
Zi-Sheng Huang, Da-Qi Xie, Li-Jun Xu, Chang-Shun Huang, Min Zheng, Yi-Jun Chen, Yin Cao   +6 more
doaj   +1 more source

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension [PDF]

British Journal of Pharmacology, 2020
Background and PurposeTetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized. TMP has a long history of beneficial effects in the treatment of many cardiovascular diseases.
Yuqin Chen, Wenju Lu, Kai Yang, Xin Duan, Mengxi Li, Xiuqing Chen, Jie Zhang, Meidan Kuang, Shiyun Liu, Xiongting Wu, Guofa Zou, Chunli Liu, Cheng Hong, Wenjun He, Jing Liao, Chi Hou, Zhe Zhang, Qiuyu Zheng, Jiyuan Chen, Nuofu Zhang, Haiyang Tang, Rebecca R. Vanderpool, Ankit A. Desai, Franz Rischard, Stephen M. Black, Joe G.N. Garcia, Ayako Makino, Jason X.‐J. Yuan, Nanshan Zhong, Jian Wang   +29 more
openaire   +4 more sources

The complete genome sequence of the thermophilic bacterium Laceyella sacchari FBKL4.010 reveals the basis for tetramethylpyrazine biosynthesis in Moutai‐flavor Daqu

MicrobiologyOpen, 2019
The genus Laceyella consists of a thermophilic filamentous bacteria. The pure isolate of Laceyella sacchari FBKL4.010 was isolated from Moutai‐flavor Daqu, Guizhou Province, China. In this study, the whole genome was sequenced and analyzed.
Dounan Li, Wei Huang, Chunxiao Wang, Shuyi Qiu   +3 more
doaj   +1 more source

Screening of High-yielding Tetramethylpyrazine Bacillus and Its Effect on the Accumulation Process of Maotai-flavor Liquor

Shipin gongye ke-ji, 2022
In order to increase and stabilize the content of tetramethylpyrazine in liquor, 13 strains of Bacillus were isolated from Maotai Daqu samples, and 5 strains with excellent protease production were selected through the preliminary screening of protease ...
Ying ZHANG, Xiaoxiao LI, Jinghui LI, Xiaomin LIU, Xiangyun XIE, Jun LU, Changwen LI, Cuiying ZHANG, Dongguang XIAO   +8 more
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Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway

Frontiers in Pharmacology, 2023
Acute lung injury (ALI) is a respiratory disorder characterized by severe inflammation of the alveoli and lung parenchyma. Tetramethylpyrazine (TMP), the main active compound in Ligusticum chuanxiong Hort (LC), can protect against lipopolysaccharide (LPS)
Simin Min, Simin Min, Weiting Tao, Dushan Ding, Xiaonan Zhang, Shidi Zhao, Yong Zhang, Xiaojie Liu, Kefei Gao, Saisai Liu, Li Li, Min Hou, Yan Li, Yan Li   +13 more
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Effects of phenolic acids on tetramethylpyrazine formation via room temperature spontaneous ammoniation of acetoin. [PDF]

Food Chem X
In this study, we aim to investigate the effects of phenolic acids on tetramethylpyrazine (TTMP) formation in low-temperature environments and discuss its possible mechanism.
Xu H, Chen X, Zhang Q, Yang Z, Tian J, Chen Q, Chen J.   +6 more
europepmc   +2 more sources

Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts via Inhibiting the Phosphorylation of AKT

Frontiers in Pharmacology, 2020
Hypertrophic scar (HS) is a serious fibrotic skin disease and often considered as a kind of benign skin tumor. Tetramethylpyrazine (TMP), the main chemical composition of the traditional Chinese medicine Chuanxiong Rhizoma, has shown significant clinical
Xue Wu, Xue Wu, Zheng Wang, Gaofeng Wu, Xiaofan Xu, Jian Zhang, Yan Li, Hong Zhang, Shuzhen Guo   +8 more
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Tetramethylpyrazine improving cerebral microcirculation in Alzheimer's Disease mice

Brain Research Bulletin
Cerebrovascular dysfunction plays a crucial role in the development and progression of Alzheimer's Disease (AD). Tetramethylpyrazine, a bioactive alkaloid monomer derived from Chinese herbal medicine Chuanxiong (Ligusticum chuanxiong), has been ...
Qingbin Wu, Xinyi Cui, Xueting Liu, Xiaochen Yuan, Peng Wang, Hongwei Li, Ruijuan Xiu   +6 more
doaj   +1 more source