Results 61 to 70 of about 282 (87)

Structure-Based Design of Acetolactate Synthase From Bacillus licheniformis Improved Protein Stability Under Acidic Conditions

Frontiers in Microbiology, 2020
Catabolic acetolactate synthase (cALS) plays a crucial role in the quality of liquor because of its ability to catalyze the synthesis of the endogenous precursor product α-acetolactate of the aromatic compound tetramethylpyrazine (TTMP) and acetoin ...
Ting Zhao, Yuan Li, Siqi Yuan, Yang Ye, Zhifu Peng, Rongqing Zhou, Jun Liu, Jun Liu, Jun Liu   +8 more
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The mechanism of Laceyella sacchari FBKL4.010 produced tetramethylpyrazine in the liquid fermentation by comparative transcriptomic techniques

Frontiers in Microbiology
Tetramethylpyrazine (TTMP) is considered a crucial flavor component in Moutai-flavored liquor. Laceyeella sacchari FBKL4.010 (L. sacchari) is the dominant species found in Moutai-flavor Daqu, and this study aims to determine the mechanism by which L ...
Xiaodan Wang, Xiaodan Wang, Wu Huang, Wu Huang, Jin Huang, Xiaoye Luo, Xiaoye Luo, Mingbo Nie, Tao Jiang, Shidong Ban, Pei Li, Pei Li   +11 more
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Screening and identification of a bacterial strain for the production of tetramethylpyrazine through solid-state fermentation and determination of its high-yield mechanism

Journal of Taibah University for Science
In this study, a strain producing a high yield (1.72 mg·g–1) of tetramethylpyrazine (TTMP) was screened under solid-state conditions from high-temperature Daqu and was identified as Bacillus velezensis using 16S rDNA molecular technology.
Wanwan Zhuansun, Jun Xu, Zhiqiang Li, Hengzhao Liu, Yin Zhao, Lulu Chen, Shufang Shan, Xin Zeng, Binyue Xin, Huawei Zeng, Qinxiang Xu   +10 more
doaj   +1 more source

From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health

Frontiers in Pharmacology
Tetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine Ligusticum wallichii (Chuanxiong), has gained significant attention for its therapeutic potential in cerebrovascular diseases and cognitive impairment, mainly ...
Xiaodi Wang, Muhan Cao, Yi Xu, Xifei Yang, Qinghua Hou   +4 more
doaj   +1 more source

Tetramethylpyrazine and renal ischemia-reperfusion injury: a systematic review and meta-analysis of preclinical studies

Frontiers in Pharmacology
ObjectivesThe aim of this systematic review and meta-analysis is to synthesize the effects and mechanisms of Tetramethylpyrazine (TMP) on renal outcomes in animal models of renal I/R injury.MethodsAnimal studies from seven electronic databases were ...
Zhongmei Fu, Lianyan Jiang, Xiaojuan Su, Hua Wang, Mingquan Li   +4 more
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Tetramethylpyrazine enhances neuroprotection and plasticity in cerebral ischemia-reperfusion injury via RhoA/ROCK2 pathway inhibition

Frontiers in Pharmacology
Tetramethylpyrazine (TMP) is an active component of the Chuanxiong, effectively crosses blood-brain barrier (BBB). It exhibits neuroprotective potential in cerebral ischemia-reperfusion injury (CIRI). This study performed middle cerebral artery occlusion/
Yixin Zhang, Xin Zhang, Xiaocheng Shi, Weijing Liao, Junbin Lin   +4 more
doaj   +1 more source

Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes

Frontiers in Pharmacology
Our study focused on the role of traditional Chinese medicine in stroke therapy, specifically targeting endothelin-1 (ET-1) in astrocytes to alleviate ischemic brain injury.
Minzhen Deng, Minzhen Deng, Minzhen Deng, Yuefang Cai, Yuefang Cai, Yu Wang, Dafeng Hu, Yan Li, Zhenqiu Ning, Chengyi Wang, Sookja Kim Chung, Yan Huang, Yan Huang, Jingbo Sun, Jingbo Sun, Lihua Zhou, Jie Li, Xiao Cheng, Xiao Cheng, Xiao Cheng   +19 more
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Mitophagy Activation via the YAP/Parkin Pathway Underlies the Neuroprotective Action of Tetramethylpyrazine in Cerebral Ischemia/Reperfusion Injury

Biomolecules
Background: Mitophagy is a critical mitochondrial quality control mechanism that limits neuronal injury following cerebral ischemia/reperfusion injury (CI/RI).
Lanxi Xu, Meiyu Wang, Yan Feng, Sihan Wang, Yihan Qian, Weiru Jiang, Jiadong Xu, Yan Fang, Yani Zhang, Lisheng Chu   +9 more
doaj   +1 more source

Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway

Frontiers in Pharmacology
BackgroundTetramethylpyrazine (TMP) is a natural alkaloid compound with antioxidant and neuroprotective effects. We hypothesized that TMP could exert neuroprotective effects by inhibiting ferroptosis through modulating iron metabolism, but its mechanism ...
Jingwei Tao, Jingwei Tao, Jingya Zhou, Hanjie Zhu, Lin Xu, Jizhou Yang, Xiaohong Mu, Xiao Fan   +7 more
doaj   +1 more source

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SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization

Frontiers in Immunology, 2023
Fu Peng, Ziwei Xing, Chen Junren
exaly