Results 61 to 70 of about 5,031 (222)

Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

JAMA Netw Open
ImportanceTetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).ObjectiveTo evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.Design, Setting, and ParticipantsThis phase 2, multicenter,
Liu X, Shang H, Wei Q, Yao X, Lian L, Dang J, Jia R, Wu Z, Li H, Niu Q, Cheng X, Zou Z, Chen S, Zhang M, Liu Y, Liu Y, Liu Q, Huang X, Wang H, Feng H, Wang S, Fan D, TBNALS group.   +22 more
europepmc   +3 more sources

Tetramethylpyrazine: A review of the most recent research

Pharmacological Research - Modern Chinese Medicine, 2022
Tetramethylpyrazine (TMP) is the main component of functional quality in vinegar. According to recent studies, TMP has a wide range of pharmacological effects, including a positive influence on the cardiovascular system, neurological system, tumors, and other disorders. This review compiled all of the most recent data on the pharmacological effects and
Tong Xu, Guanghong Chen, Xue Tong, Yuting Wu, Honglin Xu, Xin Han, Guoyong Zhang, Wenjun Ding, Bin Liu, YingChun Zhou   +9 more
openaire   +2 more sources

Functional Bread Development With Cocoa Shell Powder: Nutritional, Phytochemical, Antioxidant, and Microbiological Properties

eFood, Volume 7, Issue 2, April 2026.
Cocoa shell is an agrifood by‐product with significant potential for functional food development due to its high nutritional and bioactive profile. Incorporation of cocoa shell powder (CSP) in wheat‐based bread improved its nutritional value, prebiotic potential, phytochemicals, antimicrobial, and antioxidant properties.
Mohamed Esam Rozek, Emmanuel Duah Osei, Anthony Amotoe‐Bondzie, Marcela Slukova, Ivona Jančo, Eva Ivanišová, Miroslava Kačániová, Newlove Akowuah Afoakwah   +7 more
wiley   +1 more source

Role of carboxypeptidases to the free amino acid composition, methylpyrazine formation and sensory characteristic of under- fermented cocoa beans [PDF]

, 2010
The role of carboxypeptidases B (from porcine) and Y (from baker's yeast), applied to under-fermented cocoa beans, on the formation of cocoa-specific aroma precursors, the aroma and sensory quality after roasting was investigated.
Bakar, Jamilah, Lioe, Hanifah Nuryani, Saari, Nazamid, Selamat, Jinap, Yusep, I.   +4 more
core  

Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics [PDF]

, 2012
Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers.
Ding, Hong, Wu, Fang
core   +1 more source

Luzhou‐Flavor Baijiu Alleviates Stress‐Related Depressive‐Like Changes by NMDAR‐NO‐sGC‐cGMP Pathway

Food Safety and Health, Volume 4, Issue 2, Page 475-487, April 2026.
Luzhou‐flavor baijiu (LFB) alleviates depressive‐like phenotypes in CRS‐induced mice and protects HT22 cells from corticosterone damage, with mechanisms linked to suppressing the NMDAR‐nNOS/iNOS‐NO‐sGC‐cGMP pathway. ABSTRACT Moderate alcohol consumption has been suggested to alleviate anxiety and depression; however, it remains unclear whether Luzhou ...
Li Xiong, Yongkang Wu, Zhangjun Huang, Songtao Wang, Ping Yang, Caihong Shen, Huan Guo, Yue Xiao, Qian Bu, Hong Gao, Yina Huang   +10 more
wiley   +1 more source

Tetramethylpyrazine inhibits NETs formation induced by high glucose by regulating NRF2/HO-1 pathway

陆军军医大学学报, 2022
Objective To investigate the effect and mechanism of tetramethylpyrazine (TMP) on the formation of neutrophil extracellular traps (NETs) induced by high glucose. Methods The viability of neutrophils treated with TMP of 0, 5, 10, 20, 40, and 80 μmol/L for
CHEN Jinquan, ZHAO Long, DING Xuanheng, WANG Lingda, WEN Yan   +4 more
doaj   +1 more source

An overview of the physical and biochemical transformation of cocoa seeds to beans and to chocolate: Flavor formation [PDF]

, 2020
Source Agritrop Cirad (https://agritrop.cirad.fr/594161/)International audienceChocolate is a widely consumed product worldwide due to its exquisite flavor, which comes from the unique and fascinating cocoa flavor.
Escobar Parra, Sebastian, Rodríguez Cortina, Jader, Santander Muñoz, Margareth, Vaillant, Fabrice   +3 more
core   +1 more source

Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion

World Journal of Gastroenterology, 2003
To investigate the effect of tetramethylpyrazine (ligustrazine, TMP) on the secretion of exocrine pancreas (and biliary).In in vivo study, we investigated the effect of TMP on the secretion of pancreatic-bile juice (PBJ) in rats. Using human pancreatic duct cell line, CAPAN-1, combined with the short-circuit current (ISC) technique we further studied ...
Wen-Chao, Zhao, Jin-Xia, Zhu, Ning, Tang, Yu-Lin, Gou, Dewi Kenneth, Rowlands, Yiu-Wa, Chung, Ying, Xing, Hsiao-Chang, Chan   +7 more
openaire   +2 more sources

Advances in Hydrogel Tissue Engineering for Spinal Cord Injury Repair

Smart Medicine, Volume 5, Issue 2, April 2026.
This review systematically introduces the pathological process of spinal cord injury (SCI) and the applications and biological roles of hydrogels in SCI repair. Emerging 4D printing and gene therapy strategies are also discussed. ABSTRACT Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the ...
Ruixing Shui, Fan Ding, Dapeng Li, Guoqing Pan   +3 more
wiley   +1 more source