Results 51 to 60 of about 3,627 (215)

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination

Drug Design, Development and Therapy, 2021
Guohu Weng,1 Bo Zhou,2 Tao Liu,3 Zhengxin Huang,2 Shixiong Huang3 1Department of Encephalopathy, Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou, 570203, Hainan, People’s Republic of China; 2Department of Cardiology, Hainan ...
Weng G, Zhou B, Liu T, Huang Z, Huang S
doaj  

The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy

Molecules, 2023
The excessive intake of fluoride, one of the trace elements required to maintain health, leads to liver injury. Tetramethylpyrazine (TMP) is a kind of traditional Chinese medicine monomer with a good antioxidant and hepatoprotective function.
Shuai Zhang, Yilei Zheng, Hong Du, Wei Zhang, Haohuan Li, Yangping Ou, Funeng Xu, Juchun Lin, Hualin Fu, Xueqing Ni, Li-Jen Chang, Gang Shu   +11 more
doaj   +1 more source

Microbiome‐mediated chemical communication in insects: Implications for pest management

Pest Management Science, EarlyView.
Microbiome–semiochemical interactions involve the following processes: direct microbial synthesis, host gene regulation, precursor biotransformation, microbiome modulation and indirect ecological signaling. Abstract Insects rely on semiochemicals to regulate aggregation, mating, foraging, and host selection. This review synthesizes evidence that insect‐
Ioannis Eleftherianos, Wei Zhang, Amr Mohamed, Rasha K. Al‐Akeel, Abeer M. Alkhaibari, Nemat Keyhani, Guy Smagghe   +6 more
wiley   +1 more source

Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils.

, 1989
Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, has been used routinely in China for the treatment of stroke and angina pectoris.
C M Lee, W K Ho, H L Wen
core   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

The Effect of Tetramethylpyrazine on Hydrogen Peroxide-Induced Oxidative Damage in Human Umbilical Vein Endothelial Cells

, 2009
Tetramethylpyrazine has been widely used in traditional Chinese medicine to treat cardiovascular diseases such as atherosclerosis and hypertension. The underlying mechanism of cardioprotective effects, however, remains to be elucidated. Here, using human
Wen-Ming Li, Hong-Tao Liu, Ding, Song-Tao, Xiu-Ying Li, Jian-Yong Wu, Chao Yu, Wu, Jian-Yong, Teng, Yong-Zhen, Song-Tao Ding, Li, Wen-Ming, Liu, Hong-Tao, Gang Xu, Yu, Chao, Li, Xiu-Ying, Xu, Gang, Yong-Zhen Teng   +15 more
core   +1 more source

Magnetic Resonance Imaging Investigation of Neuroplasticity After Ischemic Stroke in Tetramethylpyrazine-Treated Rats

Frontiers in Pharmacology, 2022
Ischemic stroke elicits white matter injury typically signed by axonal disintegration and demyelination; thus, the development of white matter reorganization is needed. 2,3,5,6-Tetramethylpyrazine (TMP) is widely used to treat ischemic stroke. This study
Xue-Feng Feng, Xue-Feng Feng, Jian-Feng Lei, Man-Zhong Li, Man-Zhong Li, Yu Zhan, Yu Zhan, Le Yang, Le Yang, Yun Lu, Yun Lu, Ming-Cong Li, Ming-Cong Li, Yu-Ming Zhuang, Yu-Ming Zhuang, Lei Wang, Lei Wang, Hui Zhao, Hui Zhao   +18 more
doaj   +1 more source

Silibinin Modulates NF‐κB Activation and Heat Shock Protein in Preeclampsia‐Like Rat Model

American Journal of Reproductive Immunology, Volume 96, Issue 1, July 2026.
ABSTRACT Problem Preeclampsia (PE) is a serious human pregnancy complication and remains the most complex hypertensive disorder due to its multifactorial nature and multisystemic effects. Despite the incomplete understanding of the PE pathophysiology, it is well‐accepted that placental changes in PE are associated with oxidative stress, increasing the ...
C. F. Bannwart‐Castro, M. Romao‐Veiga, V. R. Ribeiro‐Vasques, M. T. S. Peracoli, J. C. Peracoli   +4 more
wiley   +1 more source

Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization

Angewandte Chemie, Volume 138, Issue 8, 16 February 2026.
We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde, Jonatan Babiker, Michelle Mebrahtu, Anaïs Prigent, Gauthier Foucras, Yogesh N. Aher, Francoise M. Amombo Noa, Magnus J. Johansson, Janez Košmrlj, Ross D. Jansen‐van Vuuren, Thomas Cailly, Henrik Sundén   +11 more
wiley   +2 more sources