Results 31 to 40 of about 282 (87)

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

open access: yesPhytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen   +4 more
wiley   +1 more source

Engineered Bacillus subtilis for the Production of Tetramethylpyrazine,(R,R)-2,3-Butanediol and Acetoin

open access: yesFermentation, 2023
2,3-Butanediol, acetoin and tetramethylpyrazine have a wide range of applications as important chemicals in the chemical, food and pharmaceutical fields.
Lin Shi   +8 more
doaj   +1 more source

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

open access: yesFood Frontiers, Volume 7, Issue 5, September 2026.
We developed a macrophage‐derived exosome‐based delivery system to enhance the therapeutic efficacy of puerarin (Pue) against atherosclerosis (AS). Exosomes were isolated from RAW264.7 cells, co‐cultured with Pue, and comprehensively characterized for morphology, stability, and drug loading.
Zijian Zou   +6 more
wiley   +1 more source

Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis

open access: yesFrontiers in Pharmacology, 2019
Recent published findings have demonstrated the effectiveness of combining molecules from traditional Chinese medicine with chemotherapeutic drugs to treat cancer.
Liang Zou   +7 more
doaj   +1 more source

Magnetic Resonance Imaging Investigation of Neuroplasticity After Ischemic Stroke in Tetramethylpyrazine-Treated Rats

open access: yesFrontiers in Pharmacology, 2022
Ischemic stroke elicits white matter injury typically signed by axonal disintegration and demyelination; thus, the development of white matter reorganization is needed. 2,3,5,6-Tetramethylpyrazine (TMP) is widely used to treat ischemic stroke. This study
Xue-Feng Feng   +18 more
doaj   +1 more source

Microbiome‐mediated chemical communication in insects: Implications for pest management

open access: yesPest Management Science, Volume 82, Issue 9, Page 8132-8151, September 2026.
Microbiome–semiochemical interactions involve the following processes: direct microbial synthesis, host gene regulation, precursor biotransformation, microbiome modulation and indirect ecological signaling. Abstract Insects rely on semiochemicals to regulate aggregation, mating, foraging, and host selection. This review synthesizes evidence that insect‐
Ioannis Eleftherianos   +6 more
wiley   +1 more source

The role of tetramethylpyrazine and paeoniflorin in modulating iron metabolism and ferroptosis: innovative strategies for atherosclerosis treatment

open access: yesFrontiers in Pharmacology
IntroductionAtherosclerosis (AS) is driven by lipid accumulation, inflammation, and oxidative stress, leading to endothelial dysfunction and plaque formation.
Miao Zhang   +8 more
doaj   +1 more source

Tetramethylpyrazine Preserves the Integrity of Blood-Brain Barrier Associated With Upregulation of MCPIP1 in a Murine Model of Focal Ischemic Stroke

open access: yesFrontiers in Pharmacology, 2021
Tetramethylpyrazine (TMP), a prominent ingredient of Chinese herb Ligusticum chuanxiong Hort, is known to suppress neuroinflammation and protect blood-brain barrier (BBB) integrity.
Zhuqing Jin   +3 more
doaj   +1 more source

Silibinin Modulates NF‐κB Activation and Heat Shock Protein in Preeclampsia‐Like Rat Model

open access: yesAmerican Journal of Reproductive Immunology, Volume 96, Issue 1, July 2026.
ABSTRACT Problem Preeclampsia (PE) is a serious human pregnancy complication and remains the most complex hypertensive disorder due to its multifactorial nature and multisystemic effects. Despite the incomplete understanding of the PE pathophysiology, it is well‐accepted that placental changes in PE are associated with oxidative stress, increasing the ...
C. F. Bannwart‐Castro   +4 more
wiley   +1 more source

Tetramethylpyrazine protects mitochondrial function by up-regulation of TFAM and inhibition of neuronal apoptosis in a rat model of surgical brain injury [PDF]

open access: yesIranian Journal of Basic Medical Sciences
Objective(s): Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage and mutation is widely accepted as one of the pathological processes of neurodegenerative diseases. As an mtDNA binding protein, mitochondrial transcription factor A (TFAM)
Chaoyu Wang   +5 more
doaj   +1 more source

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