Results 141 to 150 of about 2,522 (183)

<i>trans</i>-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity. [PDF]

RSC Chem Biol
Barendrecht A, Peeters HHC, Torres-García D, Shema MT, Sarris AJC, David S, Aba G, Le Gall CM, Wilkovitsch M, Verdoes M, Mikula H, Travis MA, van Kasteren SI.   +12 more
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Chemical Tagging of <i>N</i>-Alkylamine-Containing Natural Products and Pharmaceuticals through C(<i>sp</i>³)-H Functionalization. [PDF]

J Am Chem Soc
Wang Y, Zhao C, Wang T, Steele A, Joshi M, Mori S, Chatterjee A, Shen B, Disney MD, Wasa M, Wasa M.   +10 more
europepmc   +1 more source

Polymeric PEG-based bioorthogonal triggers for prodrug activation in breast cancer. [PDF]

RSC Adv
Mitry MMA, Osborn HMI, Greco F.
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Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts. [PDF]

J Am Chem Soc
Šlachtová V, Bím D, Németh K, Barańska E, Bellová S, Dračínský M, Dzijak R, Kele P, Slanina T, Vrabel M.   +9 more
europepmc   +1 more source

A Single Bioorthogonal Reaction for Multiplex Cell Surface Protein Labeling. [PDF]

J Am Chem Soc
Huang Y, Wu C, Lu A, Wang J, Liang J, Sun H, Yang L, Duan S, Berezin AA, Wu C, Zhang B, Wu YL, Tsai YH.   +12 more
europepmc   +1 more source

Identification of Actionable Targeted Protein Degradation Effector Sites through Site-Specific Ligand Incorporation-Induced Proximity (SLIP). [PDF]

J Am Chem Soc
Xiao Z, Gavriil ES, Cao F, Zhang X, Li SX, Kotelnikov S, Michalska P, Marte F, Huang C, Lu Y, Zhang Y, Bernardini E, Kozakov D, Tate EW.   +13 more
europepmc   +1 more source

Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine-Isonitrile Reaction. [PDF]

Angew Chem Int Ed Engl
Mak EC, Lee LC, Lo KK.
europepmc   +1 more source

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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics

Organic Letters, 2019
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until they are activated. The activation strategy is highly modular due to the cyclopropene's ability to be caged by various light- and enzyme-activatable groups.
Pratik Kumar, Omar Zainul, Frank M. Camarda, Ting Jiang, John A. Mannone, Wei Huang, Scott T. Laughlin   +6 more
openaire   +2 more sources

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Chemical Communications, 2013
Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest.
Herth, Matthias Manfred, Andersen, Valdemar L., Lehel, Szabolcs, Madsen, Jacob, Knudsen, Gitte Moos, Kristensen, Jesper Langgaard   +5 more
openaire   +3 more sources

Metabolic remodeling of bacterial surfaces via tetrazine ligations

Chemical Communications, 2015
Bioorthogonal click ligations are extensively used for the introduction of functional groups in biological systems.
S E, Pidgeon, M M, Pires
openaire   +2 more sources