Tetrazole Is a Novel Zinc Binder Chemotype for Carbonic Anhydrase Inhibition. [PDF]
ACS Med Chem LettGiovannuzzi S +5 more
europepmc +3 more sources
C-Glycosyl 1,2,4-triazoles: Synthesis of the 3-β-d-glucopyranosyl-1,5-disubstituted and 5-β-d-glucopyranosyl-1,3-disubstituted variants [PDF]
, 2017 K
Páhi, András +2 more
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Advanced Science, Volume 13, Issue 1, 5 January 2026.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Tetrazolium Compounds: Synthesis and Applications in Medicine
Molecules, 2015 Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj +1 more source
LCST-phase behavior and complexation with water of an ionic liquid incorporating the 5-phenyltetrazolate anion [PDF]
, 2017 The use of 5-phenyltetrazole, a bioisostere of benzoic acid, as an anion source to prepare an ionic liquid is described for the first time. Tetrabutylphosphonium 5-phenyltetrazolate undergoes phase separation from water with lower critical solution ...
Allen +41 more
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Ligase‐Catalyzed Transcription and Reverse Transcription of XNA by T3 DNA Ligase
Current Protocols, Volume 6, Issue 1, January 2026.Abstract The growing utility of xeno‐nucleic acids (XNAs) lies in their ability to extend the reach of genetic chemistry beyond the limits imposed by natural polymers. XNAs, with their diverse chemical backbones, resist enzymatic degradation and yet retain the capacity for sequence‐defined information, and have found broad applications in biotechnology.
Natalie Khamissi +2 more
wiley +1 more source
Optimasi Sifat Inhibitor Korosi Senyawa Thiaamida-pirazolindol Berdasarkan Teori Fungsional Kerapatan [PDF]
, 2016 . Corrosion inhibitor properties of thiamide pyrazolindole and its derivatives has been elucidated by means of density functional theory (DFT) at B3LYP/6-31G(d) level of theory.
Arduha, J. (Jannatin) +3 more
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A Computational Study of the NMR Chemical Shifts of Polynitropyrazoles
Magnetic Resonance in Chemistry, Volume 64, Issue 1, Page 97-113, January 2026.The 1H, 13C, 15N, and 17O chemical shifts of 91 nitro‐1H‐pyrazoles at GIAO/B3LYP/6‐311++G(d,p) level. The calculated chemical shifts were compared with available experimental data using an empirical equation that relates absolute shieldings to chemical shifts.
Arturo Alcorta +3 more
wiley +1 more source
CHIMIA, 2007 This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of
Deborah A. Longbottom +2 more
doaj +1 more source
An improved novel process for the synthesis of antihypertensive drug, Irbesartan [PDF]
, 2014 In general 5-substituted tetrazoles were prepared through the reactions of sodium azide with nitriles in an aromatic solvent in the presence of an amine salt. The present work describes process for the preparation of the 2-butyl-3-[[2’-(1H-tetrazol-5-yl)
Joshi, Narendra +2 more
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