Results 31 to 40 of about 17,991 (268)

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Pharmaceuticals, 2022
Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo   +4 more
doaj   +1 more source

6-(Tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as Novel Potent CK2 Inhibitors

Molecules, 2022
In this work, we describe the design, synthesis, and structure-activity relationship of 6-(tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as inhibitors of Casein kinase 2 (CK2).
Grigoriy V. Urakov, Konstantin V. Savateev, Svetlana K. Kotovskaya, Vladimir L. Rusinov, Alexandr A. Spasov, Denis A. Babkov, Elena V. Sokolova   +6 more
doaj   +1 more source

Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate

Molbank, 2022
The Diels–Alder reaction of ethyl 3-(1-phenyl-1H-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4H-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7H-pyrano[
Susana M. M. Lopes, Américo Lemos, José A. Paixão, Teresa M. V. D. Pinho e Melo   +3 more
doaj   +1 more source

Selective synthesis of ureas and tetrazoles from amides controlled by experimental conditions using conventional and microwave irradiation

Journal of Saudi Chemical Society, 2018
An efficient synthetic procedure has been achieved for selective synthesis of 1,5-disubstituted tetrazoles and diaryl ureas from secondary amides in situ in the presence of NaN3 and POCl3 as solvent, both by conventional and microwave methods.
Rajendran Sribalan, Andiappan Lavanya, Maruthan Kirubavathi, Vediappen Padmini   +3 more
doaj   +1 more source

Highly Active and Reusable Cu/C Catalyst for Synthesis of 5-Substituted 1H-Tetrazoles Starting from Aromatic Aldehydes

Acta Chimica Slovenica, 2020
A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed.
Reza Khalifeh, Najme Rastegar, Dariush Khalili   +2 more
doaj   +1 more source

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2

Molecules, 2022
This study represents the design and synthesis of a new set of triazole-coumarin-glycosyl hybrids and their tetrazole hybrid analogues possessing various sugar moieties and modified analogues. All the newly synthesized derivatives were screened for their
Wael A. El-Sayed, Fahad M. Alminderej, Marwa M. Mounier, Eman S. Nossier, Sayed M. Saleh, Asmaa F. Kassem   +5 more
doaj   +1 more source

Crystal structure of poly[di-μ-aqua-{5-[(1Z)-2-(4-chlorophenyl)-1-cyanoethenyl]-1,2,3,4-tetrazol-1-ido-κN1}sodium]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, [Na(C10H5ClN5)(H2O)2]n, infinite chains of [Na(H2O)2]+ cations having a diamond-shaped cross-section and running parallel to the b axis are formed.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Ahmed M. M. El-Saghier, Mustafa R. Albayati   +4 more
doaj   +1 more source

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +1 more source

Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles

Gels, 2021
Gelatin is a costless polypeptide material of natural origin, able to form hydrogels that are potentially useful in biomaterial scaffold design for drug delivery, cell cultures, and tissue engineering.
Luca Vaghi, Mauro Monti, Marcello Marelli, Elisa Motto, Antonio Papagni, Laura Cipolla   +5 more
doaj   +1 more source

Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

Organic Process Research & Development, 2020
An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles is described.
Floriane Carpentier, F. Felpin, F. Zammattio, Erwan Le Grognec   +3 more
semanticscholar   +1 more source