Results 31 to 40 of about 18,166 (271)
Molecules, 2018 The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase.
Sándor Kun +4 more
doaj +1 more source
ACS Central Science, 2019 Covalent inhibitors have recently seen a resurgence of interest in drug development. Nevertheless, compounds, which do not rely on an enzymatic activity, have almost exclusively been developed to target cysteines. Expanding the scope to other amino acids
Kathrin Bach +3 more
semanticscholar +1 more source
Recent Advances in the Synthesis of 5-Substituted 1H-Tetrazoles: A Complete Survey (2013–2018)
Synthesis, 2019 Tetrazoles are synthetic organic heterocyclic compounds comprising of high nitrogen content among stable heterocycles. Tetrazoles, chiefly 5-substituted 1H-tetrazoles have been used as a bioisosteric replacement for carboxylic acids in medicinal ...
Rupali Mittal, S. Awasthi
semanticscholar +1 more source
Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician
Infection and Drug Resistance, 2023 Frederic Lamoth1,2 1Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 2Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University ...
Lamoth F
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Concise Synthesis of Tetrazole Macrocycle [PDF]
Organic Letters, 2017 A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo
Abdelraheem +7 more
openaire +5 more sources
A Crystallographic Study of a Novel Tetrazolyl-Substituted Nitronyl Nitroxide Radical
Crystals, 2018 Spin-labelled compounds are widely used in chemistry, physics, biology, and material sciences, but the directed synthesis of some functionalized organic radicals is still a challenge.
Vasily E. Romanov +6 more
doaj +1 more source
Scientific Reports, 2023 An efficient synthesis of 5-substituted 1H-tetrazoles was successfully achieved through one-pot multi-component condensation reactions of some aromatic aldehydes or indolin-2,3-dione with malononitrile and sodium azide using diverse reaction conditions ...
Ahmed El-Sewedy +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.The sequential functionalization of novel BCP‐substituted ethynylbenziodoxolone (EBX) reagents into heteroatom‐ and BCP‐substituted alkenes is described. The addition of N, O, and S nucleophiles on the EBXs was stereoselective and generated heteroatomic Z‐vinylbenziodoxolone (VBX) reagents.
Najung Lee +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina +10 more
wiley +2 more sources
iScience, 2020 Summary: As a privileged motif, tetrazoles can be widely found in pharmaceuticals and materials science. Herein, a five-component reaction of cycloketone oxime esters, alkynes, DABCO·(SO2)2, and two molecules of trimethylsilyl azide under iron catalysis ...
Jun Zhang +3 more
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