Results 91 to 100 of about 45,106 (206)

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

In vitro functional properties of the rat bladder regenerated by the bladder acellular matrix graft. [PDF]

, 1998
PurposeTo assess the response of rat urinary bladder regenerated by the homologous bladder acellular matrix graft (BAMG) to in vitro electrical and pharmacologic stimuli.Materials and methodsIn Sprague-Dawley rats, partial cystectomy (>50%) was ...
Dahiya, R, Dahms, SE, Lue, TF, Nunes, LS, Piechota, HJ, Tanagho, EA   +5 more
core   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Bianchi C, Broad RM, Buchheit KH, Budhoo MR, Carter D, Costall B, Costa M, Craig DA, D'Amato M, Eglen RM, Engel G, Erspamer V, Feldberg W, Gale JD, Gebauer A, Gershon MD, Gozlan H, Hedge SS, Hume SP, Humphrey PP, Ivancheva C, Javid FA, Kilbinger H, Kuemmerle JF, Leysen JE, Malleron JL, Mawe GM, Nowak TV, Pan H, Racke K, Radomirov R, Satoh Y, Weber LJ, Yamamoto I   +33 more
core   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
This study was undertaken to evaluate the effect of pufferfish (Lagocephalus lagocephalus) meat poisoning on hepatic functions of Wistar rats. For this purpose, groups of rats (Lcr, Lcu+b and Lcu-b) received diet supplemented with 10% of raw or cooked ...
M Saoudi, A Abdelmouleh, F Ellouze, K Jamoussi, A El Feki   +4 more
doaj   +1 more source

Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model [PDF]

, 2012
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents.
Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morita, Kiyoshi, Nishie, Hiroyuki, Obata, Norihiko, Ouchida, Mamoru, Taniguchi, Arata, Tomotsuka, Naoto   +10 more
core   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Biomedical and pharmacological potential of tetrodotoxin-producing bacteria isolated from marine pufferfish Arothron hispidus (Muller, 1841)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
Specimens of the pufferfish Arothron hispidus collected at Parangipettai, on the southeast coast of India, were subjected to bacterial isolation and identification.
S Bragadeeswaran, D Therasa, K Prabhu, K Kathiresan   +3 more
doaj   +1 more source

Sustained synchronized neuronal network activity in a human astrocyte co-culture system [PDF]

, 2016
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is typically studied using genetically modified cellular and animal models.
Brône, Bert, Cik, Miroslav, De Vos, Winnok, Detrez, Jan R, Diels, Annick, Kuijlaars, Jacobine, Meert, Theo, Meneghello, Giulia, Nuydens, Rony, Oyelami, Tutu, Peeters, Pieter J, Rohrbacher, Jutta, Tuefferd, Marianne, Verheyen, An, Verschuuren, Marlies, Verstraelen, Peter, Versweyveld, Sofie   +16 more
core   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source