Results 121 to 130 of about 45,106 (206)

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Experimental Physiology, Volume 111, Issue 3, Page 1340-1364, 1 March 2026.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback   +3 more
wiley   +1 more source

Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial K+ buffering in central white matter

Experimental Physiology, Volume 111, Issue 3, Page 1313-1329, 1 March 2026.
Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley   +1 more source

Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish

The Journal of Physiology, Volume 604, Issue 5, Page 2083-2109, 1 March 2026.
Abstract figure legend During the first few days of development, zebrafish acquire the ability to produce increasingly refined movements that rely progressively less on the activity of primary motoneurons. At the same time, primary motoneurons undergo functional maturation, becoming increasingly capable of repetitive firing.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes [PDF]

, 1986
Several cDNA clones coding for the high molecular weight (alpha) subunit of the voltage-sensitive Na channel have been selected by immunoscreening a rat brain cDNA library constructed in the expression vector lambda gt11.
Auld, Vanessa, Catterall, William A., Davidson, Norman, Downey, William, Dowsett, Andrew, Dunn, Robert, Fritz, Larry C., Goldin, Alan L., Lester, Henry A., Lübbert, Hermann, Marshall, John, Snutch, Terry P.   +11 more
core  

Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro*

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Ece Selçuk, David S. Silcock, Amanda Foust, Vicky Bousgouni, Mar Arias‐Garcia, Chris Bakal, Mustafa B. A. Djamgoz, Pinar Uysal‐Onganer   +7 more
wiley   +1 more source

Tetrodotoxin: a brief history.

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2008
Tetrodotoxin (TTX), contained in puffer, has become an extremely popular chemical tool in the physiological and pharmacological laboratories since our discovery of its channel blocking action in the early 1960s. This brief review describes the history of discovery of TTX action on sodium channels, and represents a story primarily of my own work.
openaire   +2 more sources

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

Enhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome:A Possible Pathophysiological Explanation [PDF]

, 2007
Chapple, Christopher R., Chess-Williams, Russell, Kumar, Vivek, Surprenant, Ann Marie   +3 more
core   +1 more source

Puffer Fish Products in the United States. [PDF]

Food Saf (Tokyo)
Deeds JR, McGrath SC, Handy SM, Swajian KA.   +3 more
europepmc   +1 more source

Editorial: Highly efficient selections and applicable utilizations of aptamers as molecular recognition elements. [PDF]

Front Chem
Lou X, Sun J, Tao WA, Dong Y.
europepmc   +1 more source