Effects of Tetrodotoxin on Safety, and Sensory and Respiratory Systems: A Dose-Escalating Study in Healthy Volunteers. [PDF]
Eur J PainABSTRACT Background Chronic pain affects approximately 1.5 billion individuals worldwide, and currently available treatments often fail to provide adequate analgesia. Consequently, there is a need to explore novel analgesic compounds, including tetrodotoxin.
Kuijpers KWK +3 more
europepmc +2 more sources
6-Nitrodopamine Potentiates Catecholamine-Induced Ca<sup>2+</sup> <sub>i</sub> Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Background In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1‐adrenoceptor activation via IP3. Endothelium‐derived 6‐nitrodopamine (6‐ND) augments cardiac catecholamine actions; however, its effect on [Ca2+]i is unknown.
Britto-Júnior J +7 more
europepmc +2 more sources
Reversible cerebral vasoconstriction syndrome associated with tetrodotoxin poisoning: A case report
Journal of the American College of Emergency Physicians Open, 2021 An 81‐year‐old woman with a history of hypertension and Alzheimer's disease presented to the emergency department because of impaired consciousness. Physical examination revealed acute progressive generalized flaccid paralysis, hypertension, respiratory ...
Eiichi Kakehi +10 more
doaj +1 more source
6-Nitrodopamine Is the Most Potent Endogenous Positive Inotropic Agent in the Isolated Rat Heart
Life, 2023 Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine.
José Britto-Júnior +9 more
doaj +1 more source
From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic
Toxins, 2021 Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli +5 more
doaj +1 more source
Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
core +6 more sources
Diversity and biosynthetic potential of culturable microbes associated with toxic marine animals [PDF]
, 2013 Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported.
Chau, Rocky +3 more
core +4 more sources
Marine Drugs, 2022 Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent with changes in ...
Shana L. Geffeney +3 more
doaj +1 more source
No evidence for a culturable bacterial tetrodotoxin producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida) [PDF]
, 2015 Tetrodotoxin (TTX) is a potent neurotoxin found in the tissues of many taxonomically diverse organisms. Its origin has been the topic of much debate, with suggestions including endogenous production, acquisition through diet, and symbiotic bacterial ...
Cary, S. Craig +3 more
core +3 more sources
Marine Drugs, 2006 : Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms.
C. Ruben, Shana L. Geffeney
doaj +1 more source