Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
core +1 more source
Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
Toxins, 2014 Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan.
Vaishali Bane +4 more
doaj +1 more source
A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block [PDF]
, 2007 Voltage-gated sodium channels control the upstroke of the action potential in excitable cells of nerve and muscle tissue, making them ideal targets for exogenous toxins that aim to squelch electrical excitability.
Ahern, Christopher A. +4 more
core +2 more sources
Mutational analysis of the analgesic peptide DrTx(1-42) revealing a functional role of the amino-terminal turn. [PDF]
PLoS ONE, 2012 BACKGROUND: DrTx(1-42) (a carboxyl-terminally truncated version of drosotoxin) is a potent and selective blocker of tetrodotoxin-resistant (TTX-R) Na(+) channels in rat dorsal root ganglion neurons with analgesic activity. This purpose is to identify key
Ping Li, Shunyi Zhu
doaj +1 more source
Strategies for studying permeation at voltage-gated ion channels [PDF]
, 1991 Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core +1 more source
Current situation on analysis of marine toxins
Reviews in Analytical Chemistry, 2013 Marine toxins are a food safety concern worldwide. This review discusses current analytical methods for those toxins that are legally regulated in Europe, namely domoic acid, saxitoxin, okadaic acid, yessotoxin, pectenotoxin and azaspiracids, and all ...
Botana Ana M. +4 more
doaj +1 more source
Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]
, 2007 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core +1 more source
In Silico Analysis of Putative Paralytic Shellfish Poisoning Toxins Export Proteins in Cyanobacteria [PDF]
, 2013 Lopez-Cortes, XA (Lopez-Cortes, Xaviera A.) Univ Talca, Nanobiotechnol Div, Fraunhofer Chile Res Fdn, Ctr Syst Biotechnol, Talca, Chile.Paralytic shellfish poisoning toxins (PSTs) are a family of more than 30 natural alkaloids synthesized by ...
Fuentes-Valdes, J.J. +5 more
core +6 more sources
Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis [PDF]
, 2014 In the canon of reactions available to the organic chemist engaged in total synthesis, the Diels–Alder reaction is among the most powerful and well understood. Its ability to rapidly generate molecular complexity through the simultaneous formation of two
Albrecht +159 more
core +2 more sources