Results 71 to 80 of about 3,718 (180)

Friends or Foes? Emerging Impacts of Biological Toxins [PDF]

, 2019
Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts
Casewell, N.R., Clark, G.C., Elliott, C.T., Harvey, A.L., Jamieson, A.G., Strong, Peter, Turner, A.D.   +6 more
core   +6 more sources

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis

Muscle &Nerve, Volume 73, Issue 4, Page 663-667, April 2026.
ABSTRACT Introduction/Aims Hypokalemic periodic paralysis (HypoKPP) is an ion channelopathy causing episodic skeletal muscle weakness triggered by hypokalemia. Reduced inward rectifier K+ (Kir) channel activity contributes to membrane depolarization and paralysis, suggesting that pharmacologic activation of muscle K+ channels may restore excitability ...
Kirsten Denman, Mark M. Rich
wiley   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel, Samantha M. Holland, Felice D. Kelly, Eric M. Baker, Jared Stoller, William Packwood, Xin Li, Ramon F. Barajas Jr., Charles S. Springer Jr., Martin M. Pike   +9 more
wiley   +1 more source

Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish

The Journal of Physiology, Volume 604, Issue 5, Page 2083-2109, 1 March 2026.
Abstract figure legend During the first few days of development, zebrafish acquire the ability to produce increasingly refined movements that rely progressively less on the activity of primary motoneurons. At the same time, primary motoneurons undergo functional maturation, becoming increasingly capable of repetitive firing.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Slow synaptic transmission in frog sympathetic ganglia [PDF]

, 1986
Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R., Brown, D. A., Jones, S. W., Koch, Christof, Lancaster, B., Pennefeather, P.   +5 more
core   +2 more sources

Solitary electromechanical pulses in Lobster neurons

, 2016
Investigations of nerve activity have focused predominantly on electrical phenomena. Nerves, however, are thermodynamic systems, and changes in temperature and in the dimensions of the nerve can also be observed during the action potential.
Budvytyte, Rima, Gonzalez-Perez, Alfredo, Heimburg, Thomas, Jackson, Andrew D., Mosgaard, Lars D., Villagran-Vargas, Edgar   +5 more
core   +1 more source

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. [PDF]

, 2019
Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine
Angelopoulos, CM, Bartakova, AB, Daneman, R, Goldberg, JL, Murphy, A, Nudleman, E, Pulido, RS, Shah, SH, Weiner, GA   +8 more
core   +1 more source

Symposium on Frontiers of Molecular Neurobiology [PDF]

Membrane structure, synaptic transmission, and fibrous proteins of neurons ...

core   +1 more source