Results 81 to 90 of about 14,813 (212)

Beschreibung von Proteinbindetaschen für Funktionsstudien und de Novo-Design und die Entwicklung von Methoden zur funktionellen Klassifizierung von Proteinfamilien [PDF]

, 2004
Die Analyse der Ähnlichkeitsbeziehungen von Proteinbindetaschen ist das zentrale Thema, das in verschiedenen Variationen in dieser Arbeit bearbeitet wurde.Die grundlegende Annahme hinter dem vorgestellten Ansatz ist, daß die Funktion eines Proteins in ...
Klebe, Gerhard (Prof. Dr.), Kuhn, Daniel
core   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Structure and Encapsidation of Transmissible Gastroenteritis Coronavirus (TGEV) Defective Interfering Genomes [PDF]

, 1995
Serial undiluted passages were performed with the PUR46 strain of TGEV in swine testis (ST) cells. Total cellular RNA was analyzed at different passages after orthophosphate metabolic labeling. Three new defective RNA species of 24, 10.5, and 9.5 kb (DI-A, DI-B, and DI-C respectively) were detected at passage 30, which were highly stable and ...
A, Méndez, C, Smerdou, F, Gebauer, A, Izeta, L, Enjuanes   +4 more
openaire   +2 more sources

TGEV infection up-regulates FcRn expression via activation of NF-κB signaling [PDF]

Scientific Reports, 2016
AbstractIt has been well characterized that the neonatal Fc receptor (FcRn) transports maternal IgG to a fetus or newborn and protects IgG from degradation. We previously reported that FcRn is expressed in a model of normal porcine intestinal epithelial cells (IPEC-J2).
Jinyue Guo, Fei Li, Shaoju Qian, Dingren Bi, Qigai He, Hui Jin, Rui Luo, Shaowen Li, Xianrong Meng, Zili Li   +9 more
openaire   +2 more sources

Environmental persistence of porcine coronaviruses in feed and feed ingredients. [PDF]

PLoS ONE, 2017
Porcine Epidemic Diarrhea Virus (PEDV), Porcine Delta Corona Virus (PDCoV), and Transmissible Gastroenteritis Virus (TGEV) are major threats to swine health and contaminated feed plays a role in virus transmission.
Michaela P Trudeau, Harsha Verma, Fernando Sampedro, Pedro E Urriola, Gerald C Shurson, Sagar M Goyal   +5 more
doaj   +1 more source

Identification of a novel coronavirus in patients with severe acute respiratory syndrome [PDF]

, 2003
BACKGROUND: The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.
Becker, S. (Stephan), Berger, A. (Annemarie), Brodt, H.R., Burguiere, A.M., Cinatl, J., Doerr, H.W., Drosten, C. (Christian), Eickmann, M., Escriou, N. (Nicolas), Fouchier, R.A.M. (Ron), Grywna, K., Gunther, S., Klenk, H.D., Kolesnikova, L., Kramme, S., Manuguerra, J.C., Müller, S. (Stefanie), Osterhaus, A.D.M.E. (Albert), Panning, M., Preiser, W. (Wolfgang), Rabenau, H., Rickerts, V., Schmitz, H., Sturmer, M., Vieth, S., Werf, S. (Sylvie) van der   +25 more
core   +2 more sources

Is co‐existence and/or containment of genetically modified plants possible, and is it important?

New Zealand Journal of Agricultural Research, Volume 68, Issue 6, Page 1329-1380, December 2025.
ABSTRACT Co‐existence and containment of genetically modified (GM) plants has been a contentious issue since GM technologies were first commercially released in the mid‐1990s. In the first decade of commercial GM plant use, there were a significant number of contamination incidents resulting from GM presence in non‐GM crops and seed, some with a ...
John R. Caradus
wiley   +1 more source

All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

Journal of Animal Science and Biotechnology
Background Transmissible gastroenteritis virus (TGEV) is one of the main pathogens causing severe diarrhea of piglets. The pathogenesis of TGEV is closely related to intestinal inflammation. All-trans retinoic acid (ATRA) is the main active metabolite of
Junning Pu, Daiwen Chen, Gang Tian, Jun He, Ping Zheng, Zhiqing Huang, Xiangbing Mao, Jie Yu, Yuheng Luo, Junqiu Luo, Hui Yan, Aimin Wu, Bing Yu   +12 more
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source