Results 91 to 100 of about 138,672 (332)

The roles of endoglin gene in cerebrovascular diseases. [PDF]

, 2017
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis.
Ma, Li, Su, Hua, Zhang, Rui, Zhu, Wan
core   +2 more sources

Additional file 4: Table S4. of miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

, 2017
Multivariate Cox proportional hazard analyses of miR-4775 expression, T stage, Lymph node metastasis and distant metastasis in association with DFS and OS in 544 CRC patients. (DOCX 16 kb)
Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yu, Yang, Xisheng Liu, Weiyingqi Cui, Zhang, Meng, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng, Dongwang Yan   +16 more
openaire   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells

BMC Cancer, 2012
Background TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy.
Simms Neka A K, Rajput Ashwani, Sharratt Elizabeth A, Ongchin Melanie, Teggart Carol A, Wang Jing, Brattain Michael G   +6 more
doaj   +1 more source

Additional file 2: Table S2. of miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

, 2017
Data of antibodies used in the present research. (DOCX 17 kb)
Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yu, Yang, Xisheng Liu, Weiyingqi Cui, Zhang, Meng, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng, Dongwang Yan   +16 more
openaire   +1 more source

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

Suppression of TGFβ-induced epithelial-mesenchymal transition like phenotype by a PIAS1 regulated sumoylation pathway in NMuMG epithelial cells. [PDF]

PLoS ONE, 2010
Epithelial-mesenchymal-transition (EMT) is a fundamental cellular process that is critical for normal development and tumor metastasis. The transforming growth factor beta (TGFβ) is a potent inducer of EMT like effects, but the mechanisms that regulate ...
Stuart J Netherton, Shirin Bonni
doaj   +1 more source

General analysis of mathematical models for bone remodeling

, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
core   +1 more source

Additional file 6: Table S6. of miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

, 2017
Correlations between miR-4775 expression and Smad7, p-Smad2, p-Smad3 staining in tumor tissues from 544 CRC patients. (DOCX 16 kb)
Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yu, Yang, Xisheng Liu, Weiyingqi Cui, Zhang, Meng, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng, Dongwang Yan   +16 more
openaire   +1 more source

High Throughput Determination of TGFβ1/SMAD3 Targets in A549 Lung Epithelial Cells

PLoS ONE, 2011
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis. TGFβ1 activates a signal transduction cascade that results in the transcriptional regulation of genes in the nucleus, primarily through the DNA-binding transcription factor SMAD3.
Zhang, Y, Handley, D, Kaplan, T, Yu, H, Bais, AS, Richards, T, Pandit, KV, Zeng, Q, Benos, PV, Friedman, N, Eickelberg, O, Kaminski, N   +11 more
openaire   +5 more sources