Results 111 to 120 of about 132,620 (281)

Additional file 2: Table S2. of miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

, 2017
Data of antibodies used in the present research. (DOCX 17 kb)
Zhao, Senlin, Sun, Hongcheng, Jiang, Weiliang, Mi, Yushuai, Zhang, Dongyuan, Wen, Yugang, Cheng, Dantong, Tang, Huamei, Wu, Shaohan, Yu, Yang, Liu, Xisheng, Cui, Weiyingqi, Zhang, Meng, Sun, Xiaofeng, Zhou, Zongguang, Peng, Zhihai, Yan, Dongwang   +16 more
openaire   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

TGFβ₁ signaling via α_Vβ₆ integrin

Molecular Cancer, 2003
Background Transforming growth factor β1 (TGFβ1) is a potent inhibitor of epithelial cell growth, thus playing an important role in tissue homeostasis.
Sclabas Guido M, Schmidt Christian, Kracklauer Martin P   +2 more
doaj   +1 more source

General analysis of mathematical models for bone remodeling

, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
core   +1 more source

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Additional file 3: Table S3. of miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

, 2017
miR-4775 expression with relation to metastasis in 544 CRC patients. (DOCX 18 kb)
Zhao, Senlin, Sun, Hongcheng, Jiang, Weiliang, Mi, Yushuai, Zhang, Dongyuan, Wen, Yugang, Cheng, Dantong, Tang, Huamei, Wu, Shaohan, Yu, Yang, Liu, Xisheng, Cui, Weiyingqi, Zhang, Meng, Sun, Xiaofeng, Zhou, Zongguang, Peng, Zhihai, Yan, Dongwang   +16 more
openaire   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

2045 The role of TGFβ in driving early cystic fibrosis lung disease

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Transforming growth factor-beta (TGFβ) is a genetic modifier of cystic fibrosis (CF) lung disease. TGFβ’s pulmonary levels in young CF patients and its mechanism of action in CF are unknown.
Elizabeth L. Kramer, William Hardie, Kristin Hudock, Cynthia Davidson, Alicia Ostmann, John P. Clancy   +5 more
doaj   +1 more source