Results 71 to 80 of about 132,620 (281)

MOESM1 of Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

, 2014
Supplementary material, approximately 307 KB.
Spiegelberg, Linda, Swagemakers, Sigrid, van Ijcken, Wilfred, Oole, Edwin, Wolvius, Eppo, Essers, Jeroen, Braks, Joanna   +6 more
openaire   +1 more source

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland [PDF]

Breast Cancer Research, 2010
of A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary ...
Kohn, Ethan A, Du, Zhijun, Sato, Misako, Van Schyndle, Catherine MH, Welsh, Michael A, Yang, Yu-an, Stuelten, Christina H, Tang, Binwu, Ju, Wenjun, Bottinger, Erwin P, Wakefield, Lalage M   +10 more
openaire   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. [PDF]

, 2017
Inflammation is frequently associated with initiation, progression, and metastasis of colorectal cancer (CRC). Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1.
He, Xiangchuan, Huang, Wei, Ju, Huanyu, Karin, Michael, Li, Xia, Lopez, Elsa S, Lu, Xinliang, Ren, Huan, Tian, Linlu, Wang, Sheng Dian, Wong, Jerry, Xiao, Yun, Xing, Wenjing, Xu, Hongwei, Zhang, Fengmin, Zhu, Hongyan   +15 more
core   +1 more source

MOESM3 of A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland

, 2019
Authorsâ original file for figure ...
Kohn, Ethan, Du, Zhijun, Sato, Misako, Van Schyndle, Catherine, Welsh, Michael, Yang, Yu-an, Stuelten, Christina, Tang, Binwu, Ju, Wenjun, Bottinger, Erwin, Wakefield, Lalage   +10 more
openaire   +1 more source

Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFβ-Activated Kinase 1 Tyrosine Phosphorylation and NFκB Signaling in Multiple Myeloma and Bladder Cancer [PDF]

PLoS ONE, 2014
Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes ...
Salazar, Lisa, Kashiwada, Tamara, Krejci, Pavel, Meyer, April N, Casale, Malcolm, Hallowell, Matthew, Wilcox, William R, Donoghue, Daniel J, Thompson, Leslie Michels, Koul, Hari K   +9 more
openaire   +7 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

OncoImmunology, 2018
Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function.
Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro   +5 more
doaj   +1 more source

Targeting TGFβ signal transduction for cancer therapy

Signal Transduction and Targeted Therapy, 2021
Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. Dysregulation
Sijia Liu, Jiang Ren, Peter ten Dijke
doaj   +1 more source

MOESM7 of A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland

, 2019
Authorsâ original file for figure ...
Kohn, Ethan, Du, Zhijun, Sato, Misako, Van Schyndle, Catherine, Welsh, Michael, Yang, Yu-an, Stuelten, Christina, Tang, Binwu, Ju, Wenjun, Bottinger, Erwin, Wakefield, Lalage   +10 more
openaire   +1 more source