Results 231 to 240 of about 138,672 (332)

Adipose Tissue‐Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice

Obesity, EarlyView.
ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg, Zeeshan Ahmed, Katayoun Saatchi, Parleen K. Pandher, Yamna Rahim, Urs O. Häfeli, Sarah L. Gray   +6 more
wiley   +1 more source

SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration. [PDF]

Sci Rep
Yamasaki Y, Sakamoto K, Yashiro S, Kawa Y, Kondow A, Kubo A, Hitachi K, Inui M.   +7 more
europepmc   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin. [PDF]

iScience
Jiang X, Sellami S, Kessler J, Bachmann M, Noulet F, Russo B, Brembilla NC, Kaya G, Ivanov AI, Shutova MS, Wehrle-Haller B, Boehncke WH.   +11 more
europepmc   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, EarlyView.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

Downregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts. [PDF]

Front Med (Lausanne)
Fan X, Tao H, Kang BY, Diaz N, Baba K, Tosini G, Guo J, Yeligar SM, Sueblinvong V.   +8 more
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

WWP1 gain-of-function drives developmental anoikis through TGFβ pathway during neurodevelopment. [PDF]

Cell Death Discov
So KH, Lee S, Wong J, Lee H, Yun EJ, Jang SS, Choi HJ, Chae JH, Baek ST.   +8 more
europepmc   +1 more source

The TGFβ pathway plays a pivotal role in early embryo lineage segregation [PDF]

, 2012
Chuva de Sousa Lopes, Susana, De Sutter, Petra, Deforce, Dieter, Ghimire, Sabitri, Heindryckx, Björn, Lierman, Sylvie, O'Leary, Thomas, Van der Jeught, Margot   +7 more
core  

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source