Results 241 to 250 of about 138,672 (332)

Calibrating tissue level PDE models of ligand dynamics using single cell and spatial transcriptomics data. [PDF]

NPJ Syst Biol Appl
Daher A, Trucu D, Eftimie R.
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer. [PDF]

iScience
Mulholland-Illingworth EJ, Moore JW, Lin M, Amirkhah R, Grzesiak L, Ligeza A, Bull JA, Boen J, Valbuena GN, Gillespie MA, Lannagan TRM, Gilroy K, Mills ML, Corry SM, Ridgway RA, Belnoue-Davis HL, Dunne PD, Sansom OJ, Byrne HM, Leedham SJ.   +19 more
europepmc   +1 more source

Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells [PDF]

, 2018
Laia Caja, Kalliopi Tzavlaki, Mahsa Shahidi Dadras, E‐Jean Tan, Gad Hatem, Naga Prathyusha Maturi, Anita Morén, Lotta Wik, Yukihide Watanabe, Katia Savary, Masood Kamali-Moghaddan, Lene Uhrbom, Carl‐Henrik Heldin, Aristidis Moustakas   +13 more
openalex   +1 more source

Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives

British Journal of Pharmacology, EarlyView.
A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano, Mikako Nishida, Miho Tokumasu, Weiyang Zhao, Nahoko Yamashita, Heiichiro Udono   +5 more
wiley   +1 more source

TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K-S6RP proteins. [PDF]

Cell Mol Biol Lett
Stavropoulos A, Stamatopoulou V, Pavlos E, Manioudaki M, Sakellariou S, Stathopoulos C, Xilouri M.   +6 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer. [PDF]

Transl Oncol
Rajamanickam V, Simons ND, Rosales W, Kravchenko A, Yamazaki T, Bernard B, Piening B, Domingo E, Maughan T, Alvarez-Jimenez C, Desilvio T, Viswanath S, Whiteford M, Hayman A, O'Brien D, Kiely MX, Ahmad R, Gough MJ, Crittenden MR, Young KH.   +19 more
europepmc   +1 more source

MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGFβ Pathways [PDF]

, 2016
Petra Celá, Marek Hampl, Katherine K. Fu, Michaela Kunova Bosakova, Pavel Krejčı́, Joy M. Richman, Marcela Buchtová   +6 more
openalex   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, EarlyView.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source