Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]
, 2015 BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi +9 more
core +2 more sources
OncoImmunology, 2020 TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor promoting properties, depending on tissue and cellular context. Emerging data support a role for TGFβ in suppression of antitumor immunity.
Rita Greco +18 more
doaj +1 more source
Transforming growth factor-β in tumour development
Frontiers in Molecular Biosciences, 2022 Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function ...
Charles B. Trelford +3 more
doaj +1 more source
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]
, 2015 TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O +4 more
core +1 more source
Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]
, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara +4 more
core +3 more sources
TET2 Promotes Keloid Hyperplasia by Regulating 5hmC Modification in the TGFβ Promoter Region
Clinical, Cosmetic and Investigational Dermatology, 2023 Changying Niu,1 Shenxing Tan2 1Dermatological Department, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China; 2Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of ...
Niu C, Tan S
doaj
TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
Медицинская иммунология, 2014 . Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of
T. V. Antonova +3 more
doaj +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]
, 2020 Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro +67 more
core +2 more sources
TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]
, 2017 Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc +12 more
core +2 more sources