Results 41 to 50 of about 138,672 (332)

ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT

Медицинская иммунология, 2014
. Vascular network of placenta exhibits plasticity, and undergoes various dynamic changes in the course of pregnancy. Placental development is controlled by various cytokines and growth factors, and their ratios show strong fluctuations during pregnancy.
D. I. Sokolov, A. V. Kolobov, M. V. Lesnichija, I. N. Kostiouchek, K. V. Bolya, O. N. Arzhanova, I. M. Kvetnoy, S. A. Selkov   +7 more
doaj   +1 more source

The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells

Biomedicines, 2022
Growth differentiation factor 15 (GDF15) is known as a TGFβ-like cytokine acting on the TGFβ receptor to modulate target genes. GDF15 is regarded as a tumor suppressor gene in the human bladder and the caffeic acid phenethyl ester (CAPE) induces GDF15 ...
Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang   +8 more
doaj   +1 more source

MOESM1 of The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

, 2018
Additional file 1. Table S1: Genes in KEGG TGFBeta-Signaling Pathway. Table S2. Differentially expressed mRNA in MSS tumors. Table S3. Differentially expressed mRNA in MSI tumors.
Pellatt, Andrew, Mullany, Lila, Herrick, Jennifer, Sakoda, Lori, Wolff, Roger, Samowitz, Wade, Slattery, Martha   +6 more
openaire   +1 more source

Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway

Drug Design, Development and Therapy, 2020
Motoyasu Kato,1,2 Fumiyuki Takahashi,1,2 Tadashi Sato,1,2 Yoichiro Mitsuishi,1,2 Ken Tajima,1,2 Hiroaki Ihara,1,2 Fariz Nurwidya,1,2 Hario Baskoro,1,2 Akiko Murakami,1,2 Isao Kobayashi,1,2 Moulid Hidayat,1,2 Naoko Shimada,1– 3 Shinichi Sasaki,1,2 ...
Kato M, Takahashi F, Sato T, Mitsuishi Y, Tajima K, Ihara H, Nurwidya F, Baskoro H, Murakami A, Kobayashi I, Hidayat M, Shimada N, Sasaki S, Mineki R, Fujimura T, Kumasaka T, Niwa SI, Takahashi K   +17 more
doaj  

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

OncoImmunology, 2018
Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function.
Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro   +5 more
doaj   +1 more source

WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets [PDF]

, 2011
A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation ...
Chantry, A
core   +1 more source

TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition

Molecular Oncology, 2022
Transforming growth factor β (TGFβ) induces epithelial–mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal–epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization ...
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl‐Henrik Heldin, Aristidis Moustakas   +13 more
doaj   +1 more source

Additional file 1: Table S2. of Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer

, 2015
Correlation of signaling pathway expression in primary colon cancer slides.(DOCX 73 kb)
Bauer, Jessica, Ozkan Ozden, Akagi, Naomi, Carroll, Timothy, Principe, Daniel, Staudacher, Jonas, Spehlmann, Martina, Eckmann, Lars, Grippo, Paul, Jung, Barbara   +9 more
openaire   +1 more source

Helicobacter pyloriinfection of human gastric epithelial cells induces IL-8 and TNFα, but not TGFβ1 mRNA [PDF]

FEMS Immunology & Medical Microbiology, 2000
Helicobacter pylori (Hp) infection causes gastric ulcers and gastric carcinomas. The mechanisms of these diseases are not known but Hp induction of cytokines is believed to be involved. However, the profile as well as the involvement of cytokines induced by Hp infection is less clear.
N, Nakachi, T W, Klein, H, Friedman, Y, Yamamoto   +3 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source