Results 101 to 110 of about 431,292 (339)

Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]

, 2018
The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M, Barber, Diane L, Choi, Changhoon, Rana, Manish K   +3 more
core   +2 more sources

Exosomal MATN3 of Urine‐Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis by Activating TGF‐β [PDF]

, 2021
Zhu Guo, Weiliang Su, RongYao Zhou, Guo-qing Zhang, Shuai Yang, Xiaolin Wu, Chensheng Qiu, Wenbin Cong, Nana Shen, Jianwei Guo, Chang Liu, Shang‐You Yang, Dongming Xing, Yan Wang, Bohua Chen, Hongfei Xiang   +15 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay

BMC Research Notes, 2012
Background Transforming growth factor-β (TGF-β) is a multi-factorial peptide growth factor that has a vital role in the regulation of cell growth, differentiation, inflammation, and tissue repair.
Khan Shaukat A, Joyce Jennifer, Tsuda Takeshi   +2 more
doaj   +1 more source

Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities. [PDF]

, 2019
Although microRNAs (miRNAs) function in the control of embryonic stem cell (ESC) pluripotency, a systems-level understanding is still being developed. Through the analysis of progressive Argonaute (Ago)-miRNA depletion and rescue, including stable Ago ...
Brümmer, Anneke, Hooshdaran, Nima, Kelly, Timothy J, Tariveranmoshabad, Mito, Zamudio, Jesse R   +4 more
core  

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK

BMC Immunology, 2010
Background Cytokines of the transforming growth factor β (TGF-β) superfamily exert effects on proliferation, apoptosis and differentiation in various cell types. Cancer cells frequently acquire resistance to the anti-proliferative signals of TGF-β, which
Hilden Vera I, Huse Kanutte, Bakkebø Maren, Smeland Erlend B, Oksvold Morten P   +4 more
doaj   +1 more source

Additional file 1: of MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2

, 2019
Table S1. Mouse primers for qRT-PCR. (DOCX 15 kb)
Liu, Yang, Feng, Lu, Xu, Jia, Yang, Zhengmeng, Wu, Tianyi, Zhang, Jiajun, Shi, Liu, Zhu, Dahai, Zhang, Jinfang, Li, Gang   +9 more
openaire   +1 more source