Results 261 to 270 of about 431,292 (339)

Furin Drives Colorectal Cancer Progression and Chemoresistance Through the TGF-β/ERK Signaling Pathway. [PDF]

Cells
Poyil PK, Siraj AK, Parvathareddy SK, Begum R, Naidu PA, Thangavel S, Alobaisi K, Azam S, Al-Dayel F, Al-Kuraya KS.   +9 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Acanthospermum hispidum and Its Metabolite Stigmasterol Modulates Anti-Inflammatory Antagonism of COX-1 and TGF-β. [PDF]

Chem Biodivers
Adeboye OM, Sowemimo A, Fageyinbo MS, Adedokun O, Basit A, Olatunji OJ, Ntungwe EN.   +6 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Dapagliflozin inhibits TGF-β-induced transdifferentiation of valvular interstitial cells and mitral valvular degeneration. [PDF]

J Mol Med (Berl)
Sato R, Sakai K, Kameshima S.
europepmc   +1 more source

β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β [PDF]

Wenhui Huang, Bing Fu, Haoran Xu
openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response. [PDF]

Oncogene
Nepali PR, Gonzalez-Kozlova E, Anegondi M, Dogra N, Archer M, Chakraborty G, Tewari AK, Hopkins BD, Kyprianou N.   +8 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

The role of TMEM59L in colorectal cancer progression and its interaction with the TGF-β/Smad pathway. [PDF]

Front Oncol
Yang H, Liu J, Jiang P, Sun Y, Chen L, Zhu S.   +5 more
europepmc   +1 more source