Results 31 to 40 of about 431,292 (339)

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]

, 2016
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley, A K Miles, A Kakizuka, B Terris, BR Henderson, C Gurrieri, C Johnson, CD Morrison, CH Heldin, D G Powe, D J Boocock, DG Altman, DR Principe, G Hulman, G Jin, G van Schalkwyk, H de Thé, H Son, HK Lin, J Borrow, J Hulman, J Massagué, J Massagué, JJ Christiansen, JP Thiery, Jr McCarty KS, JYH Chan, L Kubiczkova, M E Buczek, M Mazza, MG Mathieu, P Salomoni, PM Siegel, R C Rees, R Derynck, R Parkinson, RL Camp, S Grünert, S Lamouille, S Nisole, T Regad, T Regad, V Lallemand-Breitenbach, W Green, WC Yuan, Y Katakura   +45 more
core   +1 more source

Hubungan Kadar TGF-β1 dan IFN-ɣ dengan Indeks Kronisitas Nefritis Lupus

Jurnal Kedokteran Brawijaya, 2013
Meskipun perbaikan penatalaksanaan terapi telah dilakukan dalam dua dekade terakhir , tetapi prognosis nefritis lupus tetap  tidak  memuaskan.  Oleh  karena  itu  diperlukan  suatu  biomarker  yang  dapat  menggambarkan  aktivitas  penyakit. Penelitian ini  dilakukan untuk untuk melihat peran TGF-β1 urin dan IFN-ɣ  urin sebagai ...
Indah Jayani, Kusworini Handono, Agustina Tri E   +2 more
openaire   +2 more sources

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis

Frontiers in Oncology, 2018
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of different cellular processes that are essential for tissue and organ homeostasis.
Isabel Fabregat, Isabel Fabregat, Isabel Fabregat, Daniel Caballero-Díaz, Daniel Caballero-Díaz   +4 more
doaj   +1 more source

Lumican promotes joint fibrosis through TGF‐β signaling

FEBS Open Bio, 2020
Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules.
Dahai Xiao, Tangzhao Liang, Ze Zhuang, Ronghan He, Jianhua Ren, Shihai Jiang, Lei Zhu, Kun Wang, Dehai Shi   +8 more
doaj   +1 more source

Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo [PDF]

, 2002
In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals.
Brackenbury, L.S, Carr, B V, Charleston, B, Fray, M D, Hope, Jayne, Howard, CJ, Morrison, Ivan   +6 more
core   +2 more sources

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy

Advanced Science, 2022
Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang, Shen Liu, Tao Yu, Senbo An, Ruoxian Deng, Xiaohua Tan, Janet Crane, Weixin Zhang, Dayu Pan, Mei Wan, Andrew Carr, Xu Cao   +11 more
doaj   +1 more source

A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes

Cells, 2022
Nephronectin (NPNT) is an extracellular matrix protein in the glomerular basement membrane that is produced by podocytes and is important for the integrity of the glomerular filtration barrier. Upregulated transforming growth factor β (TGF-β) and altered
Nina Sopel, Alexandra Ohs, Mario Schiffer, Janina Müller-Deile   +3 more
doaj   +1 more source

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]

, 2014
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen, Karin, Michael, Suddason, Tesha, Wu, Xuefeng   +5 more
core   +2 more sources

Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. [PDF]

PLoS ONE, 2011
BACKGROUND: Neuroendocrine activation and local mediators such as transforming growth factor-β₁ (TGF-β₁) contribute to the pathobiology of cardiac hypertrophy and failure, but the underlying mechanisms are incompletely understood.
Michael Huntgeburth, Klaus Tiemann, Robert Shahverdyan, Klaus-Dieter Schlüter, Rolf Schreckenberg, Marie-Luise Gross, Sonja Mödersheim, Evren Caglayan, Jochen Müller-Ehmsen, Alexander Ghanem, Marius Vantler, Wolfram H Zimmermann, Michael Böhm, Stephan Rosenkranz   +13 more
doaj   +1 more source

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and Tumorigenesis

Frontiers in Immunology, 2022
Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian development and disease, particularly cancer, has constantly been updated.
Baode Chen, Chenglin Mu, Zhiwei Zhang, Xuelin He, Xia Liu   +4 more
doaj   +1 more source