Results 61 to 70 of about 431,292 (339)

TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression. [PDF]

PLoS ONE, 2012
The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor ...
Sun O Park, Mukesh Kumar, Sanjeev Gupta
doaj   +1 more source

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice [PDF]

, 2017
Transforming growth factor-β (TGF-β) plays an important role in the development and maintenance of embryonic dopaminergic (DA) neurons in the midbrain.
Chang, B, Li, L, Luo, J, Nguyen, A, Tesseur, I, Woodling, NS, Wyss-Coray, T   +6 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

Molecular Oncology
Paired related homeobox 1 (PRRX1) is an inducer of epithelial‐to‐mesenchymal transition (EMT) in different types of cancer cells. We detected low PRRX1 expression in nevus but increased levels in primary human melanoma and cell lines carrying the ...
Josep R. Ferreres, Antònia Vinyals, Rafael Campos‐Martin, Roderic Espín, Sebastian Podlipnik, Raquel Ramos, Esther Bertran, Cristina Carrera, Joaquim Marcoval, Josep Malvehy, Isabel Fabregat, Susana Puig, Àngels Fabra   +12 more
doaj   +1 more source

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

Cellular Physiology and Biochemistry, 2015
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse ...
Yinan Shen, Yongpeng Wei, Zhouchong Wang, Yingying Jing, Haiguan He, Jianyong Yuan, Rong Li, Qiudong Zhao, Lixin Wei, Tian Yang, Junhua Lu   +10 more
doaj   +1 more source

MOESM1 of Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

, 2019
Additional file 1. Supplemental information including figures.
Congcong Lu, Sidoli, Simone, Kulej, Katarzyna, Ross, Karen, Wu, Cathy, Garcia, Benjamin   +5 more
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression

Cell Death and Disease
Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver ...
Josep Amengual, Ania Alay, Javier Vaquero, Ester Gonzalez-Sanchez, Esther Bertran, Aránzazu Sánchez, Blanca Herrera, Kathleen Meyer, Mate Maus, Manuel Serrano, María Luz Martínez-Chantar, Isabel Fabregat   +11 more
doaj   +1 more source

Pemberian Ekstrak Etanol Daun Salam untuk Menurunkan Ekspresi TGF-β Podosit Glomerulus Tikus Sprague dawley Diabetes Melitus [PDF]

, 2014
Latar Belakang : Diabetes melitus merupakan kelompok sindrom metabolik yang dapat mengakibatkan peningkatan growth factor pada glomerulus, salah satunya yaitu ekspresi TGF-β di podosit.
rumaolat, wiwi
core  

Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]

, 2017
While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse, Fisher, Amanda J., Gu, Hongmei, Mickler, Elizabeth A., Varre, Ananya, Vittal, Ragini   +5 more
core   +2 more sources