Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Decoding tumor–stroma interactions: from molecular crosstalk to therapeutic targets
FEBS Open BioWith this “In the Limelight: Tumor‐Stroma Interactions” special issue, FEBS Open Bio aims to highlight the relevance of the tumor stroma cells, and their interactions with the tumor cells, in the progression of cancer.
Isabel Fabregat
doaj +1 more source
Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours
Frontiers in Bioengineering and BiotechnologyDuring wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g., chronification and diabetic foot ulcer) has proven very successful.
J. Stelling-Férez +11 more
doaj +1 more source
NAC and DTT promote TGF-β1 monomer formation: demonstration of competitive binding
Journal of Inflammation, 2006 TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripheral blood monocytes spontaneously released TGF-
Frambach Gwyn +4 more
doaj +1 more source
KADAR KORTISOL, TRANSFORMING GROWTH FACTOR β (TGF-β), SERTA DERAJAT ADHESI PASCA LAPAROSKOPI DAN LAPAROTOMI (Penelitian Eksperimental pada Kelinci yang Dilakukan Abrasi Ileum) [PDF]
, 2015 Background: Intraperitoneal adhesions after abdominal surgery occurred in 50-97% cases, and the most cause is laparotomy. This research was done to know the difference between laparoscopy and laparotomy regarding the peritoneal adhesion degree, cortisol ...
Pribadi, Agung
core
Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]
, 2018 Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S +7 more
core +2 more sources
Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner [PDF]
Advanced Science, EarlyView.Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li +7 more
openalex +2 more sources
, 2019 Table S2. Gene differential expression in HCT-116/GapC9 and HCT-116/GapNC cells. (DOCX 136 kb)
Luo, Kaili +8 more
openaire +1 more source
Bioscience Journal, 2018 Mesenchymal stem cells (MSC) are multipotent cells derived from layer mesoderm and that have potential for self-renewal and cellular differentiation. These cells can be extracted from various tissues, being the main sources the bone marrow (BM) and adipose tissue (AT).
Vivian Alonso Goulart +5 more
openaire +4 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source