Results 81 to 90 of about 431,292 (339)

Additional file 1: of FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

, 2017
Figure S1. FUT8 knockdown impaired the EMT in NMuMG cells. (PDF 102 kb)
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Kannagi, Reiji, Ruey-Bing Yang   +4 more
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing

Scientific Reports
Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling.
M. Alcaraz, I. Hernández-Mármol, J. M. Puente-Cuadrado, M. Rodríguez-Valiente, A. R. Silini, O. Parolini, F. J. Nicolás   +6 more
doaj   +1 more source

The dynamic roles of TGF-β signalling in EBV-associated cancers [PDF]

, 2018
The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease.
Arvanitakis, Assoian, Cayrol, Chan, Christopher Dawson, Dalal, Derynck, Friedman, Gorsch, Gu, Ian Paterson, Kadin, Kumar, Lawrence Young, Lee Yap, Lo, MacDonald, Maeda, Moustakas, Newcom, Poh, Raftery, Segarini, Sekelsky, Sharmila Velapasamy, Yanagihara, Yap, Zhang   +27 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts

Signal Transduction and Targeted Therapy
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment.
Josep Amengual, Ester Gonzalez-Sanchez, Mariana Yáñez-Bartolome, Laura Sererols-Viñas, Aashreya Ravichandra, Celia Guiton, Noel P. Fuste, Ania Alay, Sara Hijazo-Pechero, Beatriz Martín-Mur, Marta Gut, Anna Esteve-Codina, Ana Cantos-Cortes, Rut Espinosa-Sotelo, Emilio Ramos, Teresa Serrano, Mariona Calvo, Berta Laquente, Joana Ferrer, Gabriel Pons, Andrés Mendez-Lucas, Steven Dooley, Sumera I. Ilyas, Marie Vallette, Lynda Aoudjehane, Marie Lequoy, Laura Fouassier, Cédric Coulouarn, Silvia Affò, Alexander Scheiter, Diego F. Calvisi, Tian V. Tian, Isabel Fabregat, Javier Vaquero   +33 more
doaj   +1 more source

ATBF1 Participates in Dual Functions of TGF-β via Regulation of Gene Expression and Protein Translocalization

Biomolecules, 2020
TGF-β is a critical cytokine to regulate multiple pathophysiological functions. For tumor development and progression, TGF-β was reported to play dual functions as a tumor suppressor and epithelial-mesenchymal transition (EMT) inducer.
Mei Li, Anqi Zhang, Yanan Zheng, Jiajing Li, Jiyuan Zhao   +4 more
doaj   +1 more source

The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake [PDF]

, 2016
The anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation by suppressing the expression of key genes implicated in the uptake of modified lipoproteins.
Ashlin, Tim G., Davies, Thomas S., Foka, Pelagia, Gallagher, Hayley, Michael, Daryn R., Ramji, Dipak P., Salter, Rebecca C.   +6 more
core   +2 more sources

Additional file 1: of LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer

, 2019
Table S1. Oligonucleotides used for RT-qPCR, plasmid construction, RNA pull-down, siRNA, and GapmeR. (DOCX 25 kb)
Luo, Kaili, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Huang, Zheng, Shi, Ke-Qing, Chenwei Pan, Jianmin Wu   +8 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source