Results 101 to 110 of about 1,660 (124)
TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
, 2018 Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT)
Alessia Perino +6 more
core +1 more source
Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage
, 2017 <b><i>Background:</i></b> TGR5 (G protein-coupled bile acid receptor 1, M-Bar) is a G protein-coupled cell surface receptor responsive to bile acids (BA) and different steroid hormones.
Caroline Klindt +5 more
core +1 more source
Identification et validation biologique des agonistes du récepteur TGR5
, 2007 Les acides biliaires agissent comme des molécules anti-obésité, en augmentant la dépense énergétique via l activation d un récepteur membranaire pour les acides biliaires, le TGR5.
SATO, Hiroyuki, AUWERX, Johan
core
The role and underlying mechanism of plasma membrane-bound G protein-coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that
Schoonjans, Kristina +9 more
core +1 more source
TW. TGR5 in inflammation and cardiovascular disease. Biochem Soc Trans
, 2020 TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a Gprotein-coupled receptor that was discovered as a ...
Thijs W H Pols
core
TGR5 Modulators and Methods of Use Thereof
, 2016 Discovery of compounds active as TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, cancer, and gastrointestinal ...
GIOIELLO, ANTIMO +4 more
core
TGR5 Signaling in Hepatic Metabolic Health [PDF]
Nutrients, 2020 TGR5 is a G protein-coupled bile acid receptor that is increasingly recognized as a key regulator of glucose homeostasis. While the role of TGR5 signaling in immune cells, adipocytes and enteroendocrine L cells in metabolic regulation has been well ...
Bethany P Cummings +2 more
exaly +2 more sources
Hypothalamic bile acid-TGR5 signaling protects from obesity [PDF]
Cell Metabolism, 2021 International audienceBile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues.
Julie Charton +2 more
exaly +2 more sources
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