Results 81 to 90 of about 1,660 (124)

Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling

Nature Communications
Feeding increases plasma bile acid levels while the nucleus of the solitary tract (NTS) and area postrema (AP) of the brain detect changes in hormones to regulate feeding.
Kyla Bruce, Song-Yang Zhang, Ameth N. Garrido, Melissa T. Wang, Tomás P. Bachor, Pengcheng Wang, Allison W. Xu, Zeyu Yang, Tony K. T. Lam   +8 more
doaj   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

A 5:2 Intermittent Fasting Regimen Ameliorates High‐Fat Diet‐Induced MASLD‐Associated Skeletal Muscle Impairment in Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Metabolic dysfunction–associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder worldwide. Its pathogenesis is closely linked to high‐fat diets (HFDs) and is frequently accompanied by decreased skeletal muscle quality.
Ruohua Wang, Rui Yang, Dan Hu, Tonghe Xin, ZiXin Yang, Yue Guan, Yucun Niu   +6 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance

BMC Endocrine Disorders, 2017
Background Recent studies show that bile acids are involved in glucose and energy homeostasis through activation of G protein coupled membrane receptor (TGR5) and farnesoid X receptor (FXR).
Xinfeng Yan, Peicheng Li, Zhaosheng Tang, Bo Feng   +3 more
doaj   +1 more source

Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

MedComm, Volume 7, Issue 10, October 2026.
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan, Huiru Zhang, Deyang Kong, Yu Sun, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Haizeng Zhang, Lin Feng   +10 more
wiley   +1 more source

Activation of TGR5 in dendritic cells to combat atherosclerosis

, 2014
Die Konsequenzen von Atherosklerose, wie Myokardinfarkt und Schlaganfall, sind vorrangig in der Liste der häufigsten Todesursachen weltweit. Entzündungsprozesse sind entscheidend beteiligt an dieser chronischen Krankheit der Gefäßwände.
Puchner, Teresa
core   +2 more sources

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, Volume 40, Issue 10, Page 6005-6042, October 2026.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source