Results 71 to 80 of about 1,660 (124)

Druggable Microbial Metabolism in Cardiovascular Disease: Functional Gut Microbiome Pathways Reshaping Cardiovascular Risk, Biomarkers, and Therapy [PDF]

Studies in Multidisciplinary Medical Research
The cardiovascular microbiome field is undergoing a conceptual consolidation that resembles prior inflection points in lipid biology and inflammation research: the center of gravity is shifting from descriptive association to mechanistic tractability ...
Ashkan Fallahpour Sichani, Maryam Karimian   +1 more
doaj   +1 more source

Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression

, 2018
BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is an aggressive tumor type affecting cholangiocytes. CCAs frequently arise under certain cholestatic liver conditions.
A. Martin, Perugorria, M.J., A. Caro-Maldonado, Carracedo, Arkaitz, Banales, J M, O. Erice, Marin, J.J., Munoz-Garrido, P, Caro-Maldonado, A, Martin, A, Gómez-Vallejo, V, J.J. Marin, Martín, Abraham, P. Olaizola, J.B. Andersen, J. Llop, Marin, J J, A. Santos-Laso, J.M. Banales, Erice, Oihane, O'Rourke, Colm, Marzioni, M, Jimenez-Agüero, R, Padro, Daniel, Arbelaiz, A, Trauner, M, Adorini, L., L. Adorini, V. Gómez-Vallejo, Olaizola, P., Adorini, L, Banales, Jesus M., M.J. Perugorria, Olaizola, P, Andersen, Jesper, R. Jimenez-Agüero, Bujanda, L., P. Munoz-Garrido, M. Trauner, Carracedo, A, Llop, J, Lozano, Elisa, Trauner, M., L. Bujanda, Martín-Martín, N, Perugorria, M J, A. Carracedo, Andersen, J B, Santos-Laso, A, Martín-Martín, Natalia, Lozano, E, Labiano, I., O'Rourke, C J, Padro, D, Llop, Jordi, Santos-Laso, Álvaro, Jimenez-Agüero, R., D. Padro, Bujanda, L, Caro-Maldonado, Alfredo, Gómez-Vallejo, Vanessa, Labiano, I, Arbelaiz, Ander, A. Arbelaiz, M. Marzioni, Munoz-Garrido, Patricia, I. Labiano, E. Lozano, Erice, O, N. Martín-Martín, Marzioni, M., C.J. O'Rourke   +71 more
core   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Probing the Binding Site of Bile Acids in TGR5

, 2016
TGR5 is a G-protein-coupled receptor (GPCR) mediating cellular responses to bile acids (BAs). Although some efforts have been devoted to generate homology models of TGR5 and draw structure–activity relationships of BAs, none of these studies has hitherto
Francesca De Franco (1871515), Mark Pruzanski (1871521), Nicola Giacchè (1871518), Johan Auwerx (28419), Charles Thomas (1871524), Roberto Pellicciari (1717273), Roberto Nuti (1701340), Cristina Ferrari (1871512), Antimo Gioiello (1481785), Kristina Schoonjans (140369), Antonio Macchiarulo (182335), Thijs W. H. Pols (1871527)   +11 more
core   +1 more source

TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism [PDF]

, 2011
TGR5, an emerging G protein-coupled receptor, was identified as a membrane receptor for bile acids. The expression of TGR5 and its function are distinct from the previously identified nuclear bile acid receptor, farnesoid X receptor (FXR). These two bile
Xiaosong Chen, Meng, Zhipeng, Chen, Xiaosong, Zhipeng Meng, Guiyu Lou, Huang, Wendong, Wendong Huang, Lou, Guiyu   +7 more
core   +1 more source

Investigating Overweight and Obesity Risk in Shift Workers Using Omics Technologies

Obesity Reviews, EarlyView.
ABSTRACT Night shift workers are at higher risk of developing overweight and obesity. The disruption of the physiological circadian rhythm leads to metabolic alterations, such as decreased insulin sensitivity, increased adipogenesis, and inflammation, with effects on their health and leading, among other diseases, to obesity.
Katrin Scionti, Ivana Václavková, Vanessa Schoissengeier, Karl‐Heinz Wagner   +3 more
wiley   +1 more source

TGR5 in inflammation and cardiovascular disease

, 2014
TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a G-protein-coupled receptor that was discovered as a ...
Pols, Thijs W. H.
core   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity

, 2013
Shitalkumar P Zambad, Davinder Tuli, Anoop Mathur, Sameer A Ghalsasi, Anita R Chaudhary, Shailesh Deshpande, Ramesh C Gupta, Vijay Chauthaiwale, Chaitanya DuttTorrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, IndiaBackground: Patients ...
Chauthaiwale V, Dutt C, Chaudhary AR, Deshpande S, Zambad SP, Ghalsasi SA, Tuli D, Gupta RC, Mathur A   +8 more
core  

Lachnospiraceae in the Food–Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short‐chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distinguishes established findings from hypotheses.
Ruijun Wang, Zhiqi Li, Lina Zhang, Yuanming Pan, Zhanbiao He   +4 more
wiley   +1 more source