Inorganic Nanomaterials Meet the Immune System: An Intricate Balance
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli+3 more
wiley +1 more source
Beta‐glucans have gained significant attention as an immunomodulatory biomaterial with cell‐targeting capabilities. This review comprehensively outlines the design and fabrication methods for producing beta‐glucan particles at both the micro and nanoscale and their applications in immune cell targeting, immunomodulation, and drug delivery ...
Nate Dowdall, Todd Hoare
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c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms [PDF]
I‐Cheng Ho+2 more
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Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics
Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow microparticles with complex chemistries and geometries inaccessible to molding techniques, which are used to modulate antibody titers and class switching as ...
David J. Peeler+16 more
wiley +1 more source
Peptide Dose, Affinity, and Time of Differentiation Can Contribute to the Th1/Th2 Cytokine Balance [PDF]
Paul Rogers, Michael Croft
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Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura+19 more
wiley +1 more source
Proteoglycan (Aggrecan)-Induced Arthritis in BALB/c Mice Is a Th1-Type Disease Regulated by Th2 Cytokines [PDF]
Alison Finnegan+3 more
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This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao+6 more
wiley +1 more source
The Th1/Th2 Nature of Concurrent Immune Responses to Unrelated Antigens Can Be Independent [PDF]
Nahed Ismail, Peter A. Bretscher
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Multi‐Material Gradient Printing Using Meniscus‐enabled Projection Stereolithography (MAPS)
MAPS is a new vat‐free printing technique that utilizes programmed delivery of resin droplets with custom formulations to enable multi‐material gradient printing of 3D structures with user‐defined variations in mechanical stiffness, opacity, surface energy, cell densities, and magnetic properties. Abstract Light‐based additive manufacturing methods are
Puskal Kunwar+10 more
wiley +1 more source