Results 91 to 100 of about 318,750 (310)
Cell Reports, 2017 Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Michelle A. Sallin +5 more
doaj +1 more source
Glucocorticoids and the Th1/Th2 Balance [PDF]
Annals of the New York Academy of Sciences, 2004 A bstract : Evidence accumulated over the last 5‐10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)‐12, interferon (IFN)‐γ, IFN‐α, and tumor necrosis factor (TNF)‐α by antigen‐presenting ...
openaire +3 more sources
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Plasma Th1/Th2/Th17 cytokine ratios.
, 2016 (A) Th1/Th2 (B) Th1/Th17 (C) Th2/Th17 ratios were measured in uninfected, OB- and OS-infected mice. Box plots show the median value (line), the interquartile range (box), and the minimum and maximum values (whiskers).
Chandramathi Samudi (3179997) +6 more
core +1 more source
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Cross-talk between Th1 cells and astrocytes is necessary to promote maximal Th1 differentiation.
, 2014 (A) CD4+ T cells were polarized toward Th1 cells for 4 days in conditioned medium from unstimulated or LPS-stimulated astrocytes supplemented with 10 ng/mL IL-12 (Th1) or 5 ng/mL TGFβ (Treg).
Eléonore Beurel (342137) +4 more
core +1 more source
SAT1‐Induced Spermidine Depletion Potentiates Food Allergy
Advanced Science, EarlyView.Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu +8 more
wiley +1 more source
Th1 cells in cancer-associated inflammation [PDF]
, 2017 WOS: 000394539800003The immune system is not only evolved to protect the body from pathogens, but it also recognizes and eliminates cancer cells. CD4+ helper T (Th) lymphocytes are central intercessors differentiated according to the character of ...
Akbulut Dinç, Güneş +8 more
core +1 more source
Advanced Science, EarlyView.Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu +9 more
wiley +1 more source