Results 111 to 120 of about 318,750 (310)

Multi‐Functional Smart Skin for High‐Efficiency Energy‐Saving Buildings

Advanced Science, EarlyView.
A scalable multifunctional smart skin (MSS) with broadband modulation, zero‐energy input controllable operation mode, and thermal insulation is designed by assembling thermal managing unit of high solar reflectance and low thermal conductivity and actuation unit of multi‐responsive shape‐memory effect.
Zongxu Na, Li Yu, Bo Lu, Jing Li, Xianyang Yue, Qian Wang   +5 more
wiley   +1 more source

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

Frontiers in Immunology
BackgroundInduced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1 ...
Nidhi Jadon, Sudarvili Shanthalingam, Gregory N. Tew, Lisa M. Minter, Lisa M. Minter   +4 more
doaj   +1 more source

Perioperative immune responses in cancer patients undergoing digestive surgeries

World Journal of Surgical Oncology, 2009
Background Th1/Th2 cell balance is thought to be shifted toward a Th2-type immune response not only by malignancy but also by surgical stress. The aim of this study was to estimate perioperative immune responses with respect to the Th1/Th2 balance in ...
Miyauchi Takayuki, Hanaki Norikazu, Nishioka Masanori, Ishikawa Masashi, Kashiwagi Yutaka, Ioki Hiromi, Kagawa Akihiro, Nakamura Yoichi   +7 more
doaj   +1 more source

Necrosis and expression of mixed Th1/Th2 and Th1 responses in granulomas of pleural tuberculosis patients.

, 2013
The percentage of granulomas with necrosis and expression of Th1 and Th2 cytokines were assessed microscopically. Groups include HIV positive (PLTB HIV+, n = 6) and HIV negative (PLTB HIV−, n = 6) pleural TB patients (n = 12).
Teri Roberts (366001), Liesel Muller (374986), Juanita Bezuidenhout (374985), Paul van Helden (174769), Gerhard Walzl (149313)   +4 more
core   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Modes of the initiation of T cell-mediated immune responses

Medical Review
T cell-mediated immune response is the center of adaptive immunity. Despite more than five decades of research, the knowledge of mechanisms drives the initiation of T cell-mediated immune response is still limited due to the complexity of T cell-mediated
Li Long, Yao Zhi
doaj   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Role of TH1/TH2 cytokines in HIV infection

, 1994
Different experimental approaches were used to prove or disprove the "TH1/TH2 switch theory" of HIV-infection. No increase, or even a decrease, in the production of TH2-type cytokines (IL-4, IL-5, and IL-10) by either bulk circulating mononuclear cells ...
De Carli, M., Mazzetti, M., D'Elios, M. M., Annunziato, F., Manetti, R., Del Prete, G. F., Piccinni, M. P., Romagnani, S., Ravina, A., Parronchi, P., M. M. , Parronchi, Del Prete, P. , Sampognaro, S. , Maggi, G., E., De Carli, M. P. , D'Elios, M. , Mazzetti, M. , Piccinni, MANETTI, Roberto   +20 more
core   +1 more source

Data_Sheet_1_MicroRNA124-IL6R Mediates the Effect of Nicotine in Inflammatory Bowel Disease by Shifting Th1/Th2 Balance Toward Th1.docx

, 2020
Epidemiological investigations have shown that smoking ameliorates ulcerative colitis (UC) but exacerbates Crohn's disease (CD), diseases that feature a Th2-mediated and Th1-mediated response, respectively. Cigarette extracts, especially nicotine, affect
Jing-Jing Wan (8476473), Yang Sun (132532), Xia Liu (117318), Yu Zhang (12946), Zhen Qin (411748), Peng-Yuan Wang (308862), Jie Wei (264772)   +6 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source