Results 101 to 110 of about 318,750 (310)

Bulk RNAseq of Th1, Th1/17, and Th17 cell subsets in endometriosis patients and controls

This dataset contains bulk RNA sequencing (RNAseq) differential gene expression results from circulating Th1, Th1/17, and Th17 cell subsets derived from endometriosis patients and healthy controls.
Sisnett, Danielle
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PLoS ONE, 2010
BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues, Marsilius Mues, Hans Lassmann, Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Brazilian Journal of Medical and Biological Research, 2019
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins
Xiao Chen, Xue-ling Zhang, Guo-hua Zhang, Ying-fang Gao   +3 more
doaj   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Indicii imunității la pacienții cu tuberculoză pulmonară sub influența tratamentului complex

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
La 49 de pacienți cu tuberculoză pulmonară asociată cu toxocaroză, care au urmat tratament standard antituberculos, antiparazitar și imunocorectiv, a fost studiată dinamica indicilor răspunsului imun Th1 și Th2 și prezența corelației IL-5 cu eozinofilia ...
Angela Guila, Natalia Zincenco, Corina Rotaru-Lungu, Serghei Ghinda, Valentina Chiroşca, Elena Privalova   +5 more
doaj  

Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer

Background: T-cell densities are associated with colorectal cancer outcome, but the significance of specific Th cell subsets is incompletely understood. We aimed to investigate the role of Th1 and Th2 cells and associated cytokine profiles.
Tapiainen, Vilja V., Karjalainen, Henna, Rautio, Tero, Seppälä, Toni T, Kastinen, Meeri, Elomaa, Hanna, Mecklin, Jukka-Pekka, Äijälä, Ville K, Saarnio, Juha, Mäkinen, Markus J, Mäkinen, Markus J., Wirta, Erkki-Ville, Aro, Raila, Ahtiainen, Maarit, Böhm, Jan, Tuomisto, Anne, Väyrynen, Juha P., Rahkola, Oskari, Tapiainen, Vilja V, Seppälä, Toni T., Rintala, Jukka, Meriläinen, Sanna, Häivälä, Reetta, Väyrynen, Juha P, Helminen, Olli, Kehusmaa, Akseli, Pohjanen, Vesa-Matti, Sirniö, Päivi, Ojanperä, Aino, Äijälä, Ville K., Pohjanen, Vesa‐Matti, Wirta, Erkki‐Ville, Mecklin, Jukka‐Pekka   +32 more
core   +1 more source

TH protein and dopamine content are reduced in th1 morphant larvae.

, 2013
(A) Western blot reveals the expression of TH1 protein is significantly reduced in th1-MO1 and th1-MO2 injected embryos compared with control MO (6 dpf) [F2,8 = 20.4 ...
Tom H. J. Burne (312742), Ethan K. Scott (183008), Isabel Formella (312741), Karly M. Turner (312745), Lauren R. Harms (312743), Xiaoying Cui (134632), Pei-Yun Liu (312744), Darryl W. Eyles (197739)   +7 more
core   +1 more source