Results 81 to 90 of about 104,301 (246)
, 2013 Recording of short sentences and words in frames for intonation analysisLautém district, East Timor; recording made in ...
core +1 more source
Advanced Science, EarlyView.The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui +9 more
wiley +1 more source
Glucocorticoids and the Th1/Th2 Balance [PDF]
Annals of the New York Academy of Sciences, 2004 Abstract: Evidence accumulated over the last 5‐10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)‐12, interferon (IFN)‐γ, IFN‐α, and tumor necrosis factor (TNF)‐α by antigen‐presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL‐4, IL‐10, and IL‐13 by Th2 cells.
openaire +3 more sources
Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization
Advanced Science, EarlyView.A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Advanced Science, EarlyView.A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao +15 more
wiley +1 more source
PLoS ONE, 2010 BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues +4 more
doaj +1 more source
Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source
Advanced Science, EarlyView.Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang +16 more
wiley +1 more source