Results 201 to 210 of about 286,178 (313)

Stable and Functional Regulatory T Cells for Adoptive Cell Therapy

Barrier Immunity, EarlyView.
Deprivation of CD28 signaling combined with CDK8/19 inhibition induces stable iTregs with demethylation of Treg‐DRs. Re‐stimulation of these iTregs with additional agents further enhances their suppressive function. The generated S/F‐iTregs suppress inflammation in vivo, and subset of the suppressed Tconvs is converted into de novo pTregs, contributing
Norihisa Mikami
wiley   +1 more source

Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway. [PDF]

Cancer Immunol Res
Hunt KS, Cooke S, Kuehm LM, Lobb TA, Ebert E, Beeram S, Teague RM, Brennan M, Berrien-Elliott MM, Ferris ST, Alspach E.   +10 more
europepmc   +1 more source

Seismic analysis and design of tunnels within fault ground: A review

Deep Underground Science and Engineering, EarlyView.
The research methods of seismic response of tunnels within fault ground, including field investigations, analytical solutions, physical experiments, and numerical simulations, and seismic countermeasures are discussed. The present study examines the shortcomings and limitations of the current research and design, and puts forward proposals for future ...
Xingda Wang, Yujing Jiang, Xuepeng Zhang, Yuyong Jiao, Ningbo Li, Xiao Wang, Bo Li   +6 more
wiley   +1 more source

Gut mycobiota alteration contributes to the pathogenesis of Pneumocystis pneumonia. [PDF]

J Transl Med
Chen Y, Kang H, Yang B, Feng L, Tong R, Zhao Z, Liang L, Li X, Liu X, Tong Z.   +9 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Th2 skewing in patients with disseminated coccidioidomycosis. [PDF]

JCI Insight
Thauland TJ, Nagarajan SS, Stephens AV, Jensen SL, Srivastava A, Moreno Lastre MA, Ahn TS, Bun C, Trump MT, Johnson RH, Thompson GR, Garcia-Lloret MI, Arboleda VA, Butte MJ.   +13 more
europepmc   +1 more source

Actinide 4,4′‐Bipyridine‐N,N′‐Dioxide Coordination Polymers: Cationic Framework Structures Templated by Dicyanoaurate and Tetracyanoaurate Counterions

European Journal of Inorganic Chemistry, EarlyView.
Th4+ or UO22+ actinides, neutral bipyridine‐N,N’‐dioxide ligands, and anionic cyanoaurate linkers are combined to generate a family of four coordination polymers. ‘Truss bridge’ and square grid cationic frameworks are yielded when using [Au(CN)2]− or [Au(CN)4]−, respectively, indicating a templating effect guided by either aurophilic interactions ...
Sylvain St. Louis, Thomas E. Karpiuk, Daniel B. Leznoff   +2 more
wiley   +1 more source

Naive CD4⁺ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation. [PDF]

iScience
Adhikari LP, Contreras J, Patterson KM, Moran MM, Howe EN, Plaas AHK, Reynolds JM.   +6 more
europepmc   +1 more source

Planarized and Twisted Intramolecular Charge Transfer: Small Geometric, Huge Photophysical Changes

European Journal of Organic Chemistry, EarlyView.
Molecular motion governs excited state relaxation in aminobenzonitrile donor–acceptor systems. Small structural modifications control single and dual rotations and enable distinct relaxation pathways. Fluorescence spectroscopy, Lippert–Mataga analysis, and theoretical calculations identify multiple excited states, including a dual‐emitting planarized ...
Zoe Nonie Scheller, David Liese, Gebhard Haberhauer   +2 more
wiley   +1 more source

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Sun Y, Yang X, Zhu Q, Yang R.
europepmc   +1 more source