Results 231 to 240 of about 318,750 (310)

Enhancing Treg persistence by inhibiting necroptosis restrains autoimmune pathology. [PDF]

J Clin Invest
Wu Q, Cui N, Gao L, Lu Z, Ao X, Pang R, Li X, Pan H, Xu D, Li P, Yuan J, Zou C.   +11 more
europepmc   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

DNA Immunotherapy (INO‐3107) Long‐Term Efficacy Supported by Enhanced Immunogenicity in HPV‐6/11 RRP

The Laryngoscope, EarlyView.
Adults with HPV‐6/11‐associated recurrent respiratory papillomatosis (RRP) received DNA immunotherapy INO‐3107 in a Phase 1/2 trial and were followed for one year, with additional clinical follow‐up in a long‐term extension. INO‐3107 was shown to generate increased HPV‐directed T‐cell responses in Year 1 and substantially reduced surgical procedures ...
Milan R. Amin, Peter C. Belafsky, Simon R. Best, Aaron D. Friedman, Adam M. Klein, David G. Lott, Ted Mau, Randal C. Paniello, Seth M. Pransky, Nabil F. Saba, Stefani A. Slog, Elisabeth Gillespie, Christopher Welsh, Michael Dallas, Matthew P. Morrow, Jeffrey M. Skolnik   +15 more
wiley   +1 more source

The mRNA-based RSV vaccine mRNA-1345 induces robust and durable CD4⁺ T cell responses against RSV in younger and older adults. [PDF]

Sci Adv
DiPiazza A, Marcisak E, Yu WH, Makrinos D, Kuo HH, Landy J, McGrath S, Chang X, Cavallaro M, Wu C, Essene A, Lin H, Walker L, Carfi A, Oostendorp J, Paris R, Sun Y.   +16 more
europepmc   +1 more source

Three‐Dimensional Immunofluorescence Analysis of Psoriatic Plaques Before and After Pulsed Dye Laser Treatment: Reduced T‐Cell Content Without Changes in Nerve Fiber or Blood Vessel Density

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives Pulsed dye laser (PDL) treatment for psoriasis has demonstrated its potential for treatment‐free remission periods exceeding 1 year. The mechanism leading to remission is not fully understood, but PDL is known to heat the vasculature in the skin. We hypothesized that heat diffuses from the vasculature to the surrounding environment,
Meagan Doppegieter, Nick van der Beek, Judith de Vos, H.A. Martino Neumann, Maurice C. G. Aalders, Erik N. T. P. Bakker, Ton G. van Leeuwen   +6 more
wiley   +1 more source

T Cell-Derived IFN-γ Activates Ferroptosis in Lacrimal Luminal Ductal Cells via JAK-STAT Signaling in Sjögren's Disease-Related Dry Eye. [PDF]

Invest Ophthalmol Vis Sci
Wang B, Ou Z, Liang L, Zhang R, Wang C, Zeng H, Yang X, Deng W, Wang X, Yuan J.   +9 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source