Results 251 to 260 of about 214,484 (310)

Lysophosphatidylcholine 18:2 exacerbates Th17-dominant inflammation in obese asthma. [PDF]

Lipids Health Dis
Cao L, Liu H, Shang Y, Li Z, Ge Y, Hu T, Aili A, Chang C.   +7 more
europepmc   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ's neuroprotection in Parkinson's disease. [PDF]

Front Aging Neurosci
Li X, Li X, Chen S, Wang L, Xia J, Zheng M, Zhang C, Chen X, Cai J.   +8 more
europepmc   +1 more source

Efficacy of Upadacitinib in a Middle‐Aged Man With Netherton Syndrome Refractory to Dupilumab: A Case Report

The Journal of Dermatology, EarlyView.
Bo‐Jie Yu, Pei‐Ling Li, Bing‐Sian Lin, Shou‐En Wu, Chih‐Tsung Hung   +4 more
wiley   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells. [PDF]

Front Immunol
Blamberg R, Haberkamp C, Pedersen GK, Rosenkrands I, Schleicher U, Schraml BU, Yamasaki S, Lang R.   +7 more
europepmc   +1 more source

The impact of dyslipidemia on skeletal health - from an immunoregulatory perspective. [PDF]

Front Immunol
Zhou B, Li S, Song J.
europepmc   +1 more source

Ovarian hormones and obesity drive Th17-mediated airway inflammation through estrogen receptor-α signaling. [PDF]

Am J Physiol Lung Cell Mol Physiol
Henriquez Pilier E, Cephus JY, Kuehnle SN, Tannous E, Tomasello A, McKernan KE, Peebles RS, Cahill KN, Rathmell JC, Newcomb DC.   +9 more
europepmc   +1 more source

The TPx protein of <i>Taenia solium metacestode</i> regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway. [PDF]

Front Immunol
Sun X, Mu Q, Zhou B.
europepmc   +1 more source

Bile acid scaffold engineering reveals an androstane-triol derivative as a potent immunomodulator with therapeutic efficacy in EAE. [PDF]

J Neuroinflammation
Calvo-Barreiro L, Boutitah-Benyaich I, Eixarch H, Espejo C, Gabr MT.   +4 more
europepmc   +1 more source