Results 271 to 280 of about 169,698 (304)
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Targeting the Th17 pathway in psoriasis
Journal of Leukocyte Biology, 2012Abstract Review of preclinical and clinical evidence implicating Th17 cells in psoriasis, and the therapeutic approaches to target this pathway. In recent years, the classic paradigm of Th1/Th2 CD4+ T cell-mediated immunity has evolved to include the IL-17A-producing Th17 subset, a distinct proinflammatory CD4+ T cell ...
M Merle, Elloso +2 more
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Current Molecular Medicine, 2008
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
openaire +2 more sources
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
openaire +2 more sources
Th17 cells in inflammation and autoimmunity
Autoimmunity Reviews, 2014T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways.
Ram Pyare, Singh +7 more
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Annual Review of Immunology, 2009
CD4 + T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
openaire +2 more sources
CD4 + T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce.
Thomas, Korn +3 more
openaire +2 more sources
Contextualizing TH17 cells in cancer
Nature Reviews ImmunologyThe immune system has evolved intricate and sophisticated mechanisms to recognize and eliminate tumours. Among these, T helper 17 (TH17) cells seem to have a complex role in tumour immunity. Substantial evidence indicates that TH17 cells can impair the ability of immune cells to kill tumours, but growing research suggests that TH17 cells may also be ...
Pang, Declan +3 more
openaire +3 more sources
Stem-Like Intestinal Th17 Cells Give Rise to Pathogenic Effector T Cells During Autoimmunity
Cell, 2021Orit Rozenblatt-Rosen +2 more
exaly
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells
Cell, 2020Peter J Turnbaugh +2 more
exaly