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Th17 Cells in Depression

Brain, Behavior, and Immunity, 2018
T helper 17 (Th17) cells have recently been implicated in depression, which adds to the list of several other diseases of the central nervous system (CNS) that are already known to involve Th17 cells. In CNS diseases, it is thought that the signature cytokine produced by Th17 cells, interleukin-17A (IL-17A), mediates the detrimental effects of Th17 ...
Jeffrey A Lowell, Eléonore Beurel
exaly   +5 more sources

TL1A–DR3 Interaction Regulates Th17 Cell Function and Th17-Mediated Autoimmune Disease

Journal of Experimental Medicine, 2008
T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not well understood. We show that the expression of a tumor necrosis factor receptor family member, death receptor 3 (DR3; also ...
Xuexian O Yang, Chen Dong, Qiang Tian
exaly   +2 more sources

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Human and murine Th17

Current Opinion in HIV and AIDS, 2010
The purpose of this review is to summarize the most recent discoveries in the field of phenotypic and functional characterization of human and murine Th17 cells.Human Th17 cells express CD161 and exclusively originate from CD161 precursors present in umbilical cord blood and newborn thymus in response to the combined activity of IL-1beta and IL-23.
ANNUNZIATO, FRANCESCO, COSMI, LORENZO, ROMAGNANI, SERGIO   +2 more
openaire   +2 more sources

Pharmacological Modulation of Th17

Recent Patents on Inflammation & Allergy Drug Discovery, 2009
Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic ...
Juan B, De Sanctis, Jenny V, Garmendia, Dolores, Moreno, Nancy, Larocca, Michael, Mijares, Camilo, Di Giulio, Margarita, Salazar-Bookaman, Gabriella, Wojewodka, Danuta, Radzioch   +8 more
openaire   +2 more sources

Th17 cells in inflammation

International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
openaire   +2 more sources

Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma

Gynecologic Oncology, 2014
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells are important factors in the pathogenesis of inflammatory and autoimmune diseases. However, information concerning the roles of these cells in antitumor immunity or endometrial tumorigenesis remains limited.
Wenjing, Zhang, Fei, Hou, Yan, Zhang, Yongju, Tian, Jun, Jiao, Daoxin, Ma, Beihua, Kong, Baoxia, Cui   +7 more
openaire   +2 more sources

Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity

Cancer Immunology, Immunotherapy, 2011
CD4(+) Th17 cells induce antitumor immunity leading to the eradication of established tumors. However, the mechanism of antitumour immunity and CTL activation by Th17 cells and the distinct role of Th17 and Th17-activated CTLs in antitumor immunity are still elusive.
Manjunatha, Ankathatti Munegowda, Yulin, Deng, Sean J, Mulligan, Jim, Xiang   +3 more
openaire   +2 more sources