Results 291 to 300 of about 260,137 (386)

Neutrophils and Th17 cells in neuroinflammation

, 2020
Alicia S. Wilson
openalex   +2 more sources

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

FOXP3+ T Cells-An Emerging Evidence in Periodontitis Therapeutics. [PDF]

Clin Exp Dent Res
Ünsal RBK, Hasuike A, Badawy T, Asa'ad F, Špiljak B, Yuwanati M, Roganović J, Liu Y, Brigi C, Zambrano DM, Chaurasia A.   +10 more
europepmc   +1 more source

LTα-Expressing Lymphoid-Tissue Inducer Cells Produce IL-6 and Promote the Development of Intestinal TH17 Cells in Collaboration With CD11c + Dendritic Cells

, 2011
Yūichi Ono, Takanori Kanai∥, Yohei Mikami, Tomohisa Sujino, Atsushi Hayashi, Tomomitsu Doi, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi∥   +8 more
openalex   +1 more source

New Technologies Empower Hemophilic Arthropathy Treatment: Focusing on Regenerative Medicine, Molecular Targeting, and Gene Therapy

Medicine Bulletin, EarlyView.
ABSTRACT Hemophilic arthropathy (HA), a major complication of hemophilia, is a chronic osteoarthropathy driven by repeated joint bleeding. Although traditional therapies such as coagulation factor replacement, physical rehabilitation, and surgery can manage symptoms, they cannot fundamentally repair established joint damage or break the pathological ...
Lin Sun, Yingnan Wang, Leyuan Zhao, Liqiang Lu, Fushan Hou, Chuan Yin, Kun Zhang, Yongqiang Hao, Jingke Fu   +8 more
wiley   +1 more source

Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro. [PDF]

Front Immunol
Luo D, Liu J, Ya L, Ruan C, Ou S, Wei Y, Lin Q, Huang Z, Nong K.   +8 more
europepmc   +1 more source

Nod2 is a T cell-intrinsic suppressor of Th17 cell-mediated uveitis

, 2018
Ellen J Lee, Ruth J. Napier, Paige Snow, Emily Vance, Kimberly Samson, Mary J. Mattapallil, João M. Furtado, Justine R. Smith, Rachel R Caspi, Holly L. Rosenzweig   +9 more
openalex   +1 more source

Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Constipation is a risk factor for the onset and accelerated progression of Parkinson's disease (PD), but the mechanisms underlying this association are unknown. Neuroinflammation in PD has been demonstrated in postmortem and neuroimaging studies; however, its relationship with constipation has not been investigated.
Marta Camacho, Julia C. Greenland, Alexander R.D. Peattie, Lennart R.B. Spindler, Jonathan Holbrook, Lakmini Kahanawita, Tim D. Fryer, Young T. Hong, Caroline H. Williams‐Gray   +8 more
wiley   +1 more source

The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects. [PDF]

Ann Med
Wei L, Yue Q, Yang D, Miao S, Lu M, Zhang Z, Liang X, Zhang X, Zhang Y.   +8 more
europepmc   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source