Results 61 to 70 of about 197,134 (290)

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

Th17 cell responses in spondyloarthritis

Best Practice & Research Clinical Rheumatology, 2017
Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA.
Gaston, JSH, Jadon, DR
openaire   +3 more sources

Metabolic regulation of TH17 cells [PDF]

Molecular Immunology, 2019
IL-17-producing TH17 cells have been associated with autoimmune diseases such as multiple sclerosis (MS), psoriasis, Crohn's disease, and ulcerative colitis (Han et al., 2015), many of which lack effective therapies. Identifying effective approaches to selectively suppress TH17 cell development and function represents a legitimate strategy to cure ...
Hongxing Shen, Lewis Zhichang Shi
openaire   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

Cell Reports, 2021
Summary: Sex differences in multiple sclerosis (MS) incidence and severity have long been recognized. However, the underlying cellular and molecular mechanisms for why male sex is associated with more aggressive disease remain poorly defined.
Prenitha Mercy Ignatius Arokia Doss, Muhammad Umair, Joanie Baillargeon, Reda Fazazi, Neva Fudge, Irshad Akbar, Asmita Pradeep Yeola, John B. Williams, Mickael Leclercq, Charles Joly-Beauparlant, Philippe Beauchemin, Gian Filipo Ruda, Melanie Alpaugh, Ana C. Anderson, Paul E. Brennan, Arnaud Droit, Hans Lassmann, Craig S. Moore, Manu Rangachari   +18 more
doaj   +1 more source

Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 [PDF]

, 2014
Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype by increasing expression of IL-23 ...
Kishi, Yasuhiro, Kuchroo, Vijay, Regev, Aviv, Thalhamer, Theresa, Wu, Chuan, Xiao, Sheng, Yosef, Nir, Zhu, Chen   +7 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi, Ciric, Bogoljub, Curtis, Mark T., Guo, Min-Fang, Li, Rui-Lan, Li, Yan-Hua, Ma, Cun-Gen, Rostami, A. M., Song, Guo-Bin, Sun, Man-Luan, Thome, Rodolfo, Xu, Fang, Zhang, Guang-Xian   +12 more
core   +1 more source

Persistent effects of early infant diet and associated microbiota on the juvenile immune system. [PDF]

, 2015
Early infant diet has significant impacts on the gut microbiota and developing immune system. We previously showed that breast-fed and formula-fed rhesus macaques develop significantly different gut microbial communities, which in turn are associated ...
Ardeshir, Amir, Hartigan-O'Connor, Dennis J, Lu, Ding, Méndez-Lagares, Gema, Narayan, Nicole R, Van Rompay, Koen KA   +5 more
core   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source