Results 101 to 110 of about 22,410 (257)

Th2 cells: help for helminths. [PDF]

, 1994
Richard M. Locksley
openalex   +1 more source

Th1 and Th2 cells in autoimmunity [PDF]

Clinical and Experimental Immunology, 1995
Lucette Pelletier, Ramanathan Sheela, P. Druet   +2 more
openaire   +4 more sources

A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer

Advanced Science, EarlyView.
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li   +6 more
wiley   +1 more source

Scale‐Up of Human Amniotic Epithelial Cells Through Regulation of Epithelial‐Mesenchymal Plasticity Under Defined Conditions

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Freshly isolated human amniotic epithelial cells (hAECs) from full‐term amniotic membranes include mature epithelial cells as well as cells in a senescent state. During in vitro culture, hAECs undergo epithelial‐mesenchymal transition (EMT) and enter a partial epithelial‐mesenchymal transition (pEMT) state (E/M hybrid) resembling early developmental ...
Wangping Hao, Yi Luo, Jia Tian, Yuefeng Lu, Yangyang Cui, Ying Zhang, Xiao Jin, Hongjuan Ye, Mengqi Lu, Jinjia Song, Weiqing Zhou, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization

Frontiers in Immunology
BackgroundTh2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary.
Beiping Miao, Lihua Mo, Lihua Mo, Shihan Miao, Xiwen Zhang, Haoyue Zheng, Yixuan Dong, Bailing Xie, Yuanyi Zhang, Yun Liao, Yun Liao, Yu Liu, Ping Tang, Pingchang Yang   +13 more
doaj   +1 more source

UnPaSt: unsupervised patient stratification by differentially expressed biclusters in omics data [PDF]

arXiv
Most complex diseases, including cancer and non-malignant diseases like asthma, have distinct molecular subtypes that require distinct clinical approaches. However, existing computational patient stratification methods have been benchmarked almost exclusively on cancer omics data and only perform well when mutually exclusive subtypes can be ...
arxiv  

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

A Real-World Study of Tofacitinib in Indian Patients with Refractory Moderate-to-Severe Atopic Dermatitis, its Economic Considerations and Immunological Rationale

Indian Dermatology Online Journal
Background: The response of atopic dermatitis (AD) to different biologics and JAK inhibitors (JAKibs) is variable due to the varied immunological endotypes of AD.
Kabir Sardana, Savitha Sharath, Sumitra Kumari Meena, Ananta Khurana, Bhawuk Dhir   +4 more
doaj   +1 more source

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms [PDF]

, 1998
I‐Cheng Ho, David Lo, Laurie H. Glimcher   +2 more
openalex   +1 more source

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Advanced Science, EarlyView.
Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao, Yuhan Zhang, Zhi Hu, Shengwen Chen, Qiaolin Wang, Yong Zeng, Huiqi Yin, Junpeng Zhao, Yijing Zhan, Changxing Gao, Yue Xin, Bing Chen, Stijn van der Veen, Ming Zhao, Deyu Fang, Qianjin Lu   +15 more
wiley   +1 more source