Results 231 to 240 of about 401,370 (283)
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Journal of Theoretical Biology, 1994
We present and analyze a model for the cross-regulation of the Th1 and Th2 helper cell subsets during an immune response by the regulatory cytokines interferon-gamma (IFN)-gamma) and interleukin-10 (IL-10). IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of Th2 cells.
M A, Fishman, A S, Perelson
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We present and analyze a model for the cross-regulation of the Th1 and Th2 helper cell subsets during an immune response by the regulatory cytokines interferon-gamma (IFN)-gamma) and interleukin-10 (IL-10). IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of Th2 cells.
M A, Fishman, A S, Perelson
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Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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Current Opinion in Hematology, 2001
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
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After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
C, Dong, R A, Flavell
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TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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Human “TH9” cells are a subpopulation of PPAR-γ+ TH2 cells
Science immunology, 2019The transcription factor PPAR-γ plays a vital role in the generation of IL-9–producing TH cells. Licensing interleukin-9 production Whereas the biological roles of T helper 1 (TH1), TH2, and TH17 cells are reasonably well established, the functions of ...
C. Micossé +17 more
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Immunology Today, 1997
Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
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Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
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Signaling pathways in Th2 development
Immunological Reviews, 2004Summary: In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell‐mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T‐helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells ...
Kerri A, Mowen, Laurie H, Glimcher
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Springer Seminars in Immunopathology, 1999
Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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International archives of allergy and immunology, 1992
Human CD4+ T cell clones secreting different patterns of cytokines similar to TH1 and TH2 cells described in mice have been demonstrated. These human TH1 and TH2 clones are produced in response to different antigens and exhibit distinct functional properties. TH1 clones are produced in response to intracellular bacteria and viruses, do not provide help
ROMAGNANI, SERGIO +11 more
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Human CD4+ T cell clones secreting different patterns of cytokines similar to TH1 and TH2 cells described in mice have been demonstrated. These human TH1 and TH2 clones are produced in response to different antigens and exhibit distinct functional properties. TH1 clones are produced in response to intracellular bacteria and viruses, do not provide help
ROMAGNANI, SERGIO +11 more
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Redirecting Th2 Responses in Allergy
1999Atopic diseases are genetically determined disorders which affect approximately 20%–30% of the general population in developed countries and whose prevalence is increasing over the last decades. They are characterized by an enhanced ability of B lymphocytes to produce IgE antibodies in response to certain groups of otherwise innocuous environmental ...
PARRONCHI, PAOLA +2 more
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