Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]
, 1996 We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA +6 more
core
Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon
Nature Communications, 2017 T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells (DCs) are vital for the induction of T-cell responses, the DC subpopulations that induce Th2 cells in the intestine are unidentified.
J. Mayer +5 more
semanticscholar +1 more source
Anatomy of a Discovery: M1 and M2 Macrophages
Frontiers in Immunology, 2015 M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom.
Charles Dudley Mills
doaj +1 more source
Tracking implicit trajectories [PDF]
, 1995 Output tracking of implcitly defined reference trajectories is examined. A continuous-time nonlinear dynamical system is constructed that produces explicit estimates of time-varying implicit trajectories.
Getz, Neil H., Marsden, Jerrold E.
core
Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]
, 2019 Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara +14 more
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Dissecting the enigma of scleroderma: possible involvement of the kynurenine pathway
Pteridines, 2017 The kynurenine pathway (KP) is the metabolic pathway via which L-tryptophan is converted to nicotinamide. It serves important immune-regulatory roles. This article will review the evidence for involvement of the KP in scleroderma and present a possible ...
Noakes Rowland
doaj +1 more source
Polarizing T and B cell responses by APC-targeted subunit vaccines.
Frontiers in Immunology, 2015 Current influenza vaccines mostly aim at the induction of specific neutralizing antibodies. While antibodies are important for protection against a particular virus strain, T cells can recognize epitopes that will offer broader protection against ...
Gunnveig eGrødeland +3 more
doaj +1 more source
Role of eosinophils in protective immunity against secondary nematode infections
Immunological Medicine, 2019 Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues.
Koubun Yasuda, Etsushi Kuroda
doaj +1 more source
Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation [PDF]
, 2020 Ieva Saulīte +14 more
openalex +1 more source
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
core +1 more source