Results 141 to 150 of about 10,640,595 (395)

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

Journal of Experimental Medicine, 1999
The role of T helper type 1 (Th1) and Th2 cells in tumor immunity was investigated using Th cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice.
T. Nishimura, K. Iwakabe, M. Sekimoto, Y. Ohmi, T. Yahata, M. Nakui, Takehito Sato, S. Habu, Hiroyuki Tashiro, Marimo Sato, A. Ohta   +10 more
semanticscholar   +1 more source

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]

, 1996
We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA, Clare-Salzler, M, Forsthuber, T, Herschenfeld, A, Kaufman, DL, Lehmann, PV, Tian, J   +6 more
core  

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]

, 2012
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT, Anthony, BJ, Li, Y, McManus, D   +3 more
core   +4 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma

Respiratory Research, 2009
Background Allergic asthma is characterized by airway hyperresponsiveness (AHR) and allergic inflammation of the airways, driven by allergen-specific Th2 cells.
Van Oosterhout Antoon JM, Van Esch Betty CAM, Gras Renée, Vissers Joost LM, Motta Alexandre C, Nawijn Martijn C   +5 more
doaj   +1 more source

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

Journal of Experimental Medicine, 1997
Airway inflammation is believed to stimulate mucus production in asthmatic patients. Increased mucus secretion is an important clinical symptom and contributes to airway obstruction in asthma.
L. Cohn, R. Homer, Anthony D Marinov, J. Rankin, K. Bottomly   +4 more
semanticscholar   +1 more source

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources

Maintenance of pathogenic Th2 cells in allergic disorders

Allergology International, 2017
Immunological memory is an important protective mechanism that enables host organisms to respond rapidly and vigorously to pathogens that have been previously encountered. In addition to the protective function, memory CD4+ T helper (Th) cells play a central role in the pathogenesis of chronic inflammatory disorders, including asthma. Recently, several
Kenta Shinoda, Kiyoshi Hirahara, Toshinori Nakayama   +2 more
openaire   +4 more sources

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source

Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics

Advanced Materials, Volume 37, Issue 15, April 16, 2025.
Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow microparticles with complex chemistries and geometries inaccessible to molding techniques, which are used to modulate antibody titers and class switching as ...
David J. Peeler, Rujie Sun, Ceren Kütahya, Patrick Peschke, Kun Zhou, Giulia Brachi, Jonathan Yeow, Omar Rifaie‐Graham, Jonathan P. Wojciechowski, Thomas F. F. Fernandez Debets, Vernon LaLone, Xin Song, Krunal Polra, Paul F. McKay, John S. Tregoning, Robin J. Shattock, Molly M. Stevens   +16 more
wiley   +1 more source